Affect-modulated startle reflex and dopamine D4 receptor gene variation.
Affect-modulated startle reflex and dopamine D4 receptor gene variation.
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DOI：
10.1111/j.1469-8986.2009.00923.x
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发表时间：
2010
期刊：
影响因子：
3.7
通讯作者：
P. Pauli;A. Conzelmann;R. Mucha;P. Weyers;C. Baehne;A. Fallgatter;C. Jacob;K. Lesch
中科院分区：
文献类型：
--
作者：
P. Pauli;A. Conzelmann;R. Mucha;P. Weyers;C. Baehne;A. Fallgatter;C. Jacob;K. Lesch
情感调节的声音惊吓反应（ASR）可能是一个有前途的指标，情绪反应作为一种内表型（遗传学和表型之间的中间水平），我们预计与DRD 4多态性。因此，在114名健康志愿者中检测了情感调节的ASR，其中74名缺乏DRD 4 7 R等位基因（7 R缺失组）和41名至少具有一个DRD 4 7 R等位基因（7 R组）。结果显示，在7 R缺失组中存在众所周知的情感调节ASR。然而，7 R组的特点是情感调节的ASR变钝，特别是对不愉快图片的惊吓增强减少。探索性评估的5-HTT，COMT和DAT多态性和情感调节的ASRwere not found. Results之间的关联发言DRD 4多态性在调节情绪反应的重要性，也为情感调节的ASR作为一种内表型的有用性。
The affect-modulated acoustic startle response (ASR) might be a promising indicator for emotional reactivity as an endophenotype (an intermediate level between genetics and phenotypes), which we expected to be associated with the DRD4 polymorphism. Therefore, the affect-modulated ASR was examined in 114 healthy volunteers, 74 lacking the DRD4 7R allele (7R-absent group) and 41 with at least one DRD4 7R allele (7R group). Results revealed the well-known affect-modulated ASR in the 7R-absent group. The 7R group, however, was characterized by a blunted affect-modulated ASR, especially by a reduced startle potentiation toward unpleasant pictures. Associations between the exploratory assessed 5-HTT, COMT, and DAT polymorphisms and affect-modulated ASR were not found. Results speak for the importance of the DRD4 polymorphism in modulating emotional responses and also for the usefulness of the affect-modulated ASR as an endophenotype.