Inflammasomes in Inflammation-Induced Cancer.
Inflammasomes in Inflammation-Induced Cancer.
复制标题
炎症诱发的癌症中的炎症小体。
DOI：
10.3389/fimmu.2017.00271
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发表时间：
2017
影响因子：
7.3
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Lin C;Zhang J
炎性小体是一种重要的多蛋白复合物，在炎症免疫反应中发挥作用。炎性小体的激活会导致caspase-1的自激活以及随后的proIL-1β和proIL-18的裂解，这是炎症表现的关键来源。近年来，人们对炎性小体在肿瘤中的作用进行了广泛的研究，特别是在炎症诱导的肿瘤中。在不同和特定的情况下，炎性小体在癌症发展中表现出不同甚至相反的作用。在某些情况下，炎性小体通过外源性途径启动致癌作用，并通过内源性途径维持恶性肿瘤微环境。相反，炎性小体还通过称为细胞凋亡的专门程序性细胞死亡和免疫调节功能发挥抗癌作用。炎性小体被激活的阶段和隔室强烈影响最终的免疫效果。本文就炎性小体在炎症诱发的肿瘤，特别是胃肠道肿瘤和皮肤肿瘤中的作用进行了系统的综述。此外，还介绍了炎性小体相关产品的治疗应用现状和潜在的未来发展方向。
The inflammasome is an important multiprotein complex that functions during inflammatory immune responses. The activation of inflammasome will lead to the autoactivation of caspase-1 and subsequent cleavage of proIL-1β and proIL-18, which are key sources of inflammatory manifestations. Recently, the roles of inflammasomes in cancers have been extensively explored, especially in inflammation-induced cancers. In different and specific contexts, inflammasomes exhibit distinct and even contrasting effects in cancer development. In some cases, inflammasomes initiate carcinogenesis through the extrinsic pathway and maintain the malignant cancer microenvironment through the intrinsic pathway. On the contrary, inflammasomes also exert anticancer effects by specialized programmed cell death called pyroptosis and immune regulatory functions. The phases and compartments in which inflammasomes are activated strongly influence the final immune effects. We systemically summarize the functions of inflammasomes in inflammation-induced cancers, especially in gastrointestinal and skin cancers. Besides, information about the current therapeutic use of inflammasome-related products and potential future developing directions are also introduced.