Excitation and inhibition of neurons in the trigeminal nucleus caudalis following periaqueductal gray stimulation.
Excitation and inhibition of neurons in the trigeminal nucleus caudalis following periaqueductal gray stimulation.
复制标题
导水管周围灰质刺激后三叉神经尾核神经元的兴奋和抑制。
DOI：
10.1139/y78-021
复制
发表时间：
1978
影响因子：
2.1
通讯作者：
E. Puil
中科院分区：
文献类型：
--
作者：
R. Andersen;J. P. Lund;E. Puil
电刺激去脑猫中脑导水管周围灰质（periaqueductal gray matter，CG）或中缝背核（dorsal raphé nucleus，DR）（3-4次，300 Hz，30-150微安），可减少或消除刺激牙髓或眶下神经引起的开颌反射反应。此外，CG或DR刺激抑制了12的16个三叉神经核尾侧神经元激活其感觉传入输入的反应。10个其他神经元记录在相同的网站，并经常在同一时间，但不响应所使用的感觉输入，兴奋相同的刺激CG或DR。这种兴奋性反应被阻断静脉注射纳洛酮（0.1-0.2毫克/公斤）。这表明，CG和DR刺激兴奋的神经元可能是参与刺激或麻醉镇痛期间感觉传递突触前和突触后抑制的中间神经元。
Electrical stimulation (3-4 shocks, 300 Hz, 30-150 microamperemeter) of the periaqueductal gray matter (CG) or dorsal raphé nucleus (DR) of decerebrate cats reduced or abolished the jaw-opening reflex response evoked by stimulation of either the tooth pulp or infraorbital nerve. In addition, CG or DR stimulation inhibited the response of 12 out of 16 trigeminal nucleus caudalis neurons to activation of their sensory afferent inputs. Ten other neurons recorded in the same sites, and often at the same time, but which did not respond to the sensory inputs utilized, were excited by identical stimuli to CG or DR. This excitatory response was blocked by intravenously administered naloxone (0.1-0.2 mg/kg). It is suggested that those neurons which are excited by CG and DR stimulation may be interneurons involved in pre- and post-synaptic inhibition of sensory transmission during stimulus-produced or narcotic analgesia.