Differences in colorectal carcinoma stage and survival by race and ethnicity
Differences in colorectal carcinoma stage and survival by race and ethnicity
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作者：
Chien, C;Morimoto, LM;Li, CI
背景。在美国，与非西班牙裔白人相比，患有结直肠癌 (CRC) 的黑人病情更为晚期，死亡率也更高。有关其他种族/族裔的数据有限，特别是亚洲/太平洋岛民和西班牙裔白人亚组。方法。作者利用参与监测、流行病学和最终结果计划的 11 个基于人群的癌症登记处的数据，评估了 1988 年至 2000 年诊断为 CRC 的 154,103 名受试者中 1.8 个不同种族/民族与疾病阶段和死亡率之间的关系。 结果。与非西班牙裔白人相比，黑人、美洲印第安人、中国人、菲律宾人、韩国人、夏威夷人、墨西哥人、南美洲/中美洲人和波多黎各人被诊断出患有 III 期或 TV CRC 的可能性高出 10-60%。另一方面，日本人患晚期结直肠癌的风险降低了 20%。就死亡率而言，黑人、美洲印第安人、夏威夷人和墨西哥人的死亡风险高出 20-30%，而中国人、日本人和印度/巴基斯坦人的死亡风险低 10-40%。结论。作者观察到结直肠癌患者晚期癌症和死亡率的风险存在许多种族/民族差异，而且亚裔/太平洋岛民和西班牙裔白人亚组的这些风险存在相当大的差异。尽管这些差异的病因是多因素的，但针对结直肠癌不良结局风险较高的种族/族裔人群制定筛查和治疗计划可能是减少这些差异的重要手段。癌症2005； 104：629-39。 (c) 2005 年美国癌症协会。
BACKGROUND. In the United States, blacks with colorectal carcinoma (CRC) presented with more advanced-stage disease and had higher mortality rates compared with non-Hispanic whites. Data regarding other races/ethnicities were limited, especially for Asian/Pacific Islander and Hispanic white subgroups.METHODS. Using data from 11 population-based cancer registries that participate in the Surveillance, Epidemiology and End Results program, the authors evaluated the relation among 1.8 different races/ethnicities and disease stage and mortality rates among 154,103 subjects diagnosed with CRC from 1988 to 2000.RESULTS. Compared with non-Hispanic whites, blacks, American Indians, Chinese, Filipinos, Koreans, Hawaiians, Mexicans, South/Central Americans, and Puerto Ricans were 10-60% more likely to be diagnosed with Stage III or TV CRC. Alternatively, Japanese had a 20% lower risk of advanced-stage CRC. With respect to mortality rates, blacks, American Indians, Hawaiians, and Mexicans had a 20-30% greater risk of mortality, whereas Chinese, Japanese, and Indians/ Pakistanis had a 10-40% lower risk.CONCLUSIONS. The authors observed numerous racial/ethnic disparities in the risks of advanced-stage cancer and mortality among patients with CRC, and there was considerable variation in these risks across Asian/Pacific Islander and Hispanic white subgroups. Although the etiology of these disparities was multifactorial, developing screening and treatment programs that target racial/ethnic populations with elevated risks of poor CRC outcomes may be an important means of reducing these disparities. Cancer 2005; 104:629-39. (c) 2005 American Cancer Society.