MESOSTRIATAL DOPAMINE MARKERS IN AGED LONG-EVANS RATS WITH SENSORIMOTOR IMPAIRMENT
MESOSTRIATAL DOPAMINE MARKERS IN AGED LONG-EVANS RATS WITH SENSORIMOTOR IMPAIRMENT
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DOI：
10.1016/0197-4580(94)00157-x
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发表时间：
1995-03-01
影响因子：
4.2
通讯作者：
GALLAGHER, M
中科院分区：
文献类型：
--
作者：
BURWELL, RD;LAWLER, CP;GALLAGHER, M
在人类和实验室动物中观察到与正常衰老相关的中纹状体多巴胺系统的变化，但这些非病理性变化的具体行为后果在很大程度上是未知的。本研究（a）评估了正常衰老对中纹状体多巴胺系统标记物的影响，（B）检查了该系统中与年龄相关的变化与反应时间表现下降的关系。与年轻大鼠相比，老年大鼠中脑多巴胺（DA）和二羟苯乙酸（DOPAC）水平降低，但没有证据表明D-1或D-2受体结合密度或多巴胺摄取部位密度发生了与年龄相关的变化。老年大鼠按反应时表现分组时，观察到一些差异。老年RT-未受损大鼠表现出较高的密度D-1结合在rostrodorsal纹状体补丁区，但较低的整体水平的DA。在尾侧纹状体，老年RT-未受损大鼠表现出较低的DA和较高的DOPAC水平。
Changes in the mesostriatal dopamine system associated with normal aging are observed in both human and laboratory animals, but the specific behavioral consequences of these nonpathological changes are largely unexplored. The present study (a) assessed the effects of normal aging on markers for the mesostriatal dopamine system, and (b) examined the relationship of age-related changes in this system to decline in reaction time performance. Decreased levels of midbrain dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) were observed in the aged rats as compared to young, but there was no evidence for age-related changes in the density of D-1 or D-2 receptor binding or the density of dopamine uptake sites. Some differences were observed when the aged rats were grouped according to reaction time performance. Aged RT-unimpaired rats exhibited higher density of D-1 binding in rostrodorsal striatal patch areas, but lower overall levels of DA. In caudal striatum, aged RT-unimpaired rats exhibited lower DA and higher DOPAC levels.