A model of lymphocyte recirculation.

A model of lymphocyte recirculation.
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DOI:
10.1016/s0167-5699(97)01036-0
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发表时间:
1997-05
期刊:
Immunology today
影响因子:
--
通讯作者:
D. Stekel;Claire E. Parker;Martin A. Nowak
D. Stekel;Claire E. Parker;Martin A. Nowak
中科院分区:
其他
文献类型:
--
作者:
D. Stekel;Claire E. Parker;Martin A. Nowak

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Dov Stekel、Claire帕克和Martin Nowak提出了血液、脾脏和淋巴系统之间T细胞再循环的数学模型。淋巴细胞再循环和本地化的经典实验的比较表明,简单的动力学足以解释这些器官之间的淋巴细胞稳态,血液中的T细胞计数是高度敏感的再循环参数的变化。
Dov Stekel, Claire Parker and Martin Nowak present a mathematical model of T-cell recirculation between blood, spleen and the lymphatic system. Comparison with classical experiments on lymphocyte recirculation and localization demonstrates that simple kinetics are sufficient to explain lymphocyte homeostasis between these organs, and that T-cell counts in blood are highly sensitive to changes in the recirculation parameters.