Cigarette smoking and the risk for cartilage loss and knee pain in men with knee osteoarthritis
Cigarette smoking and the risk for cartilage loss and knee pain in men with knee osteoarthritis
复制标题
DOI：
10.1136/ard.2006.056697
复制
发表时间：
2007-01-01
影响因子：
27.4
通讯作者：
Felson, D. T.
中科院分区：
文献类型：
--
作者：
Amin, S.;Niu, J.;Felson, D. T.
目的：探讨吸烟对膝关节骨关节炎患者膝关节软骨丢失和疼痛的影响。方法：159名有症状的膝关节骨关节炎患者参加了一项为期30个月的前瞻性自然病史研究。在基线和15个月和30个月的随访中，使用磁共振成像(MRI)对症状较重的膝关节进行成像。采用全器官MRI评分半定量方法对胫股内侧关节、胫股内侧关节和髌股关节软骨进行评分。在基线和随访时，使用视觉模拟疼痛评分(0-100 mm)评估膝关节疼痛的严重程度。结果：在159名男性中，19名(12%)在基线时是当前吸烟者。现在吸烟的男性比不吸烟的男性年轻(平均年龄62(9)岁比69岁(9岁))，瘦(平均体重指数28.9(3.2)岁比31.3(4.8)kg/m(2))。在调整了年龄、体重指数和基线软骨评分后，目前吸烟的男性被发现在胫股内侧关节(优势比(OR)2.3，95%可信区间(CI)1.0至5.4)和髌股关节(OR 2.5，95%可信区间1.1至5.7)发生软骨丢失的风险增加。在基线(60.5比45.0，p，0.05)和随访时(59.4比44.3，p<；0.05)，当前吸烟者的调整疼痛评分也高于不吸烟的男性。结论：与不吸烟的男性相比，患有膝骨性关节炎的男性有更大的软骨丢失和更严重的膝关节疼痛。
Objective: To examine the effects of smoking on cartilage loss and pain at the knee in individuals with knee osteoarthritis.Methods: 159 men with symptomatic knee osteoarthritis who participated in a 30-month, prospective, natural history study of knee osteoarthritis were examined. The more symptomatic knee was imaged using magnetic resonance imaging (MRI) at baseline, and again at 15 and 30 months of follow-up. Cartilage was scored using the Whole-Organ MRI Score semiquantitative method at the medial and lateral tibiofemoral joints and at the patellofemoral joint. At baseline and follow-up visits, the severity of knee pain was assessed using a Visual Analogue Scale pain score (0-100 mm).Results: Among the 159 men, 19 (12%) were current smokers at baseline. Current smokers were younger (mean (standard deviation (SD)) age 62 (9) v 69 (9) years) and leaner (mean ( SD) body mass index (BMI): 28.9 (3.2) v 31.3 (4.8) kg/m(2)) than men who were not current smokers. When adjusted for age, BMI and baseline cartilage scores, men who were current smokers were found to have an increased risk for cartilage loss at the medial tibiofemoral joint (odds ratio (OR) 2.3, 95% confidence interval (CI) 1.0 to 5.4) and the patellofemoral joint (OR 2.5, 95% CI 1.1 to 5.7). Current smokers also had higher adjusted pain scores at baseline (60.5 v 45.0, p, 0.05) and at follow-up (59.4 v 44.3, p < 0.05) than men who were not current smokers.Conclusions: Men with knee osteoarthritis who smoke sustain greater cartilage loss and have more severe knee pain than men who do not smoke.