Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development.
Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development.
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发表时间：
1999-08
期刊：
影响因子：
4.6
通讯作者：
D. Parichy;J. Rawls;S. J. Pratt;T. Whitfield;Stephen L. Johnson
中科院分区：
文献类型：
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作者：
D. Parichy;J. Rawls;S. J. Pratt;T. Whitfield;Stephen L. Johnson
Kit受体在促进黑素细胞迁移和存活中的相对作用尚未解决。我们发现，在斑马鱼，斑马鱼，色素模式突变稀疏对应于一个直系同源的c-kit。这一发现使我们能够进一步阐明这种c-kit相关基因在黑素细胞形态发生中的形态发生作用。我们对斑马鱼黑素细胞发育的分析表明，本研究中鉴定的c-kit同源基因是胚胎黑素细胞正常迁移和存活所必需的。我们还发现，与小鼠相反，我们已经确定的斑马鱼c-kit基因对造血或原始生殖细胞发育不是必需的。这些意想不到的差异可能反映了进化分化的c-kit功能基因复制事件后，硬骨鱼。
The relative roles of the Kit receptor in promoting the migration and survival of amniote melanocytes are unresolved. We show that, in the zebrafish, Danio rerio, the pigment pattern mutation sparse corresponds to an orthologue of c-kit. This finding allows us to further elucidate morphogenetic roles for this c-kit-related gene in melanocyte morphogenesis. Our analyses of zebrafish melanocyte development demonstrate that the c-kit orthologue identified in this study is required both for normal migration and for survival of embryonic melanocytes. We also find that, in contrast to mouse, the zebrafish c-kit gene that we have identified is not essential for hematopoiesis or primordial germ cell development. These unexpected differences may reflect evolutionary divergence in c-kit functions following gene duplication events in teleosts.