Guanine nucleotides: key regulators of hormone receptor-adenylate cyclase interaction.
Guanine nucleotides: key regulators of hormone receptor-adenylate cyclase interaction.
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鸟嘌呤核苷酸：激素受体-腺苷酸环化酶相互作用的关键调节剂。
作者：
A. M. Spiegel;R. Downs
许多多肽激素、前列腺素和儿茶酚胺通过增加各自靶细胞中的细胞内 cAMP 浓度来发挥其生理（和病理生理）作用。激素作用的第一步是与特定的质膜受体结合，导致膜结合酶 AC1 的激活和 cAMP 的形成。因此，了解激素如何激活 AC 是了解激素作用机制的核心。过去十年中许多实验室进行的研究已经开始澄清这个问题。这些研究得出的主要概念之一是鸟嘌呤核苷酸 (GN) 在调节激素对 AC 的影响中发挥着关键作用。本综述将重点关注 GN 在激素受体-AC 相互作用调节中的作用。我们将 1) 详细说明 GN 是 AC 激素刺激所必需的证据； 2) 描述表明 GN 与 G 单元相互作用的实验，并且 G 单元是 AC 的离散组件...
MANY polypeptide hormones, prostaglandins, and catecholamines exert their physiological (and pathophysiological) effects by increasing intracellular cAMP concentration in their respective target cells. The first step in hormone action, binding to a specific plasma membrane receptor, leads to activation of the membranebound enzyme AC1 and formation of cAMP. Understanding how hormones activate AC, then, is central to understanding the mechanism of hormone action. Studies from numerous laboratories performed over the past decade have begun to clarify this problem. One of the major concepts to emerge from these studies is that guanine nucleotides (GN) play a critical role in mediating the effects of hormones on AC. This review will focus on the involvement of GN in regulation of hormone receptor-AC interaction. We will 1) detail the evidence that GN are required for hormonal stimulation of AC; 2) describe experiments showing that GN interact with a G unit2 and that the G unit is a discrete component of the AC...