Trends Over Time in Tobacco-Specific Nitrosamines (TSNAs) in Whole Tobacco and Smoke Emissions From Cigarettes Sold in Canada
Trends Over Time in Tobacco-Specific Nitrosamines (TSNAs) in Whole Tobacco and Smoke Emissions From Cigarettes Sold in Canada
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DOI：
10.1093/ntr/ntx103
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发表时间：
2018-05-01
影响因子：
4.7
通讯作者：
Hammond, David
中科院分区：
文献类型：
--
作者：
Czoli, Christine D.;Hammond, David
简介：烟草特有的亚硝胺 (TSNA) 是强效致癌物。 TSNA 的水平可以通过制造实践进行修改。 2000 年代，加拿大销售的卷烟中的 TSNA 含量因烟草熟化工艺的变化而降低。当前的研究检查了未来十年的 TSNA 水平，以考察随时间变化的趋势。方法：使用单向方差分析 (ANOVA) 和线性回归模型，根据《烟草报告条例》向加拿大卫生部提交的数据，检查了 2005 年至 2011/2012 年加拿大三大烟草公司生产的 1809 个品牌的全部烟草成分和 191 个品牌的主流烟雾排放量。 N-亚硝基新烟草碱 (NAT) (p
Introduction: Tobacco-specific nitrosamines (TSNAs) are potent carcinogens. Levels of TSNAs can be modified through manufacturing practices. In the 2000s, TSNA levels in cigarettes sold in Canada were reduced by changes in tobacco curing processes. The current study examined TSNA levels over the following decade to examine trends over time.Methods: Data submitted to Health Canada under the Tobacco Reporting Regulations were used to examine whole tobacco constituents for 1809 brands and mainstream smoke emissions for 191 brands manufactured by Canada's three leading cigarette companies from 2005 through 2011/12 using one-way analysis of variances (ANOVAs) and linear regression models.Results: Levels of N-nitrosoanatabine (NAT) (p