VENTILATORY RESPONSE OF THE UNRESTRAINED AND UNANESTHETIZED HAMSTER TO CO2
VENTILATORY RESPONSE OF THE UNRESTRAINED AND UNANESTHETIZED HAMSTER TO CO2
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DOI：
10.1152/ajplegacy.1954.179.1.146
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发表时间：
1954-01-01
影响因子：
--
通讯作者：
CHAPIN, JL
中科院分区：
文献类型：
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作者：
CHAPIN, JL
介绍了一种在不使用麻醉或任何物理约束的情况下测量小动物通气量的方法。它包括将动物封闭在气密室中，并记录由于吸入潮气量的加温和润湿而导致的室内压力增加。呼气时，压力福尔斯下降。已知绝对压力变化、空气温度、吸入空气的湿度和腔室体积，可以计算潮气量。将仓鼠暴露于20%O_2和N_2中的CO_2浓度范围（0-35%）中。当吸入的气体混合物中含有约20%CO2时，发生峰值通气。
A method is presented for measuring ventilation of small animals without the use of anesthesia or any physical restraint. It consists of enclosing the animal in an airtight chamber and recording the pressure increase within the chamber resulting from the warming and wetting of the inspired tidal volume. Upon expiration the pressure falls. Knowing the absolute pressure change, air temperature, humidity of the inspired air and the chamber volume, the tidal volume can be calculated. Hamsters were exposed to a spectrum of CO2 concentrations (0-35%) in 20% O2 and N2- The ventilatory responses were recorded. Peak ventilation occurred when the inspired gas mixture contained about 20% CO2.