ASSOCIATION BETWEEN VISUAL FUNCTION AND SUBRETINAL DRUSENOID DEPOSITS IN NORMAL AND EARLY AGE-RELATED MACULAR DEGENERATION EYES.
ASSOCIATION BETWEEN VISUAL FUNCTION AND SUBRETINAL DRUSENOID DEPOSITS IN NORMAL AND EARLY AGE-RELATED MACULAR DEGENERATION EYES.
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DOI：
10.1097/iae.0000000000001454
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发表时间：
2017-07
期刊：
影响因子：
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通讯作者：
Owsley C
中科院分区：
文献类型：
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作者：
Neely D;Zarubina AV;Clark ME;Huisingh CE;Jackson GR;Zhang Y;McGwin G Jr;Curcio CA;Owsley C
在黄斑健康正常的老年眼或年龄相关性黄斑变性（AMD）的早期阶段，研究通过多模式视网膜成像确定的视网膜下玻璃状核沉积物（SDD）与视功能之间的相关性。根据基于彩色眼底照片的AREDS 9步分类系统（正常=第1步，早期AMD=第2-4步）定义每只眼睛的AMD状态。视觉功能测量最佳矫正明视视力，对比敏感度，光敏感度，中间视力，低亮度赤字，杆介导的暗适应。通过多模态成像（彩色眼底照片、红外反射和眼底自发荧光图像、光谱域光学相干断层扫描）识别SDD。样本包括1，202只眼（958只眼正常健康，244只眼早期AMD）。在正常眼中，SDD与任何评价的视觉功能无关。在患有早期AMD的眼睛中，患有SDD的眼睛与没有SDD的眼睛相比，暗适应明显延迟（平均延迟4分钟），p=0.0213。然而，这种关联在年龄调整后减弱，p=0.2645。早期AMD眼的其他视功能与SDD无关。在一项专门针对正常黄斑健康和AMD早期阶段的眼睛的研究中，早期AMD伴SDD眼睛的暗适应较慢，主要归因于SDD眼睛的年龄较大;他们没有表现出其他视觉功能的缺陷。正常黄斑健康的老年眼的SDD与任何评估的视觉功能无关。
To examine the association between subretinal drusenoid deposits (SDD) identified by multimodal retinal imaging and visual function in older eyes with normal macular health or in the earliest phases of age-related macular degeneration (AMD). AMD status for each eye was defined according to the AREDS 9-step classification system (normal=step 1, early AMD=steps 2–4) based on color fundus photographs. Visual functions measured were best-corrected photopic visual acuity, contrast sensitivity, and light sensitivity, mesopic visual acuity, low luminance deficit, and rod-mediated dark adaptation. SDD were identified through multi-modal imaging (color fundus photographs, infrared reflectance and fundus autofluorescence images, spectral-domain optical coherence tomography). The sample included 1,202 eyes (958 eyes with normal health, 244 eyes with early AMD). In normal eyes SDD were not associated with any visual function evaluated. In eyes with early AMD, dark adaptation was markedly delayed in eyes with SDD versus no SDD (4-minute delay on average), p=0.0213. However this association diminished after age adjustment, p=0.2645. Other visual functions in early AMD eyes were not associated with SDD. In a study specifically focused on eyes in normal macular health and in the earliest phases of AMD, early AMD eyes with SDD have slower dark adaptation, largely attributable to the older ages of eyes with SDD; they did not exhibit deficits in other visual functions. SDD in older eyes in normal macular health are not associated with any visual functions evaluated.