Children's attentional biases and 5-HTTLPR genotype: potential mechanisms linking mother and child depression.
Children's attentional biases and 5-HTTLPR genotype: potential mechanisms linking mother and child depression.
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DOI：
10.1080/15374410902851705
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
McGeary J
中科院分区：
文献类型：
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作者：
Gibb BE;Benas JS;Grassia M;McGeary J
我们研究了特定认知（注意力偏差）和遗传（5-HTTLPR）风险因素在抑郁症代际传递中的作用。首先集中在母亲的抑郁症（MDD）和儿童的注意力偏差的历史之间的联系，我们发现，儿童的母亲与抑郁症的历史，在他们的孩子的生活，与儿童的母亲没有抑郁症的历史，表现出更大的注意力回避悲伤的面孔。这种注意力偏向只针对悲伤的面孔，而不是高兴或愤怒的面孔。也有初步证据表明，这种关系在携带5-HTTLPR S或LG等位基因的儿童中比在LA等位基因纯合子的儿童中更强。接下来，在多波前瞻性随访期间，在能力-压力框架内概念化母亲的抑郁症状水平，我们发现了三向儿童5-HTTLPR ×注意力偏差×母亲抑郁症状相互作用预测儿童抑郁症状的证据。具体来说，母亲和孩子的抑郁症状水平之间的关系随着时间的推移是最强的儿童携带5-HTTLPR S或LG等位基因谁也表现出注意力回避悲伤的面孔。这些发现为儿童5-HTTLPR基因型和悲伤面孔的注意偏向在抑郁症代际传递中的作用提供了初步支持。
We examined the roles of specific cognitive (attentional bias) and genetic (5-HTTLPR) risk factors in the intergenerational transmission of depression. Focusing first on the link between maternal history of major depressive disorder (MDD) and children’s attentional biases, we found that children of mothers with a history of MDD during their children’s lives, compared to children of mothers with no depression history, exhibited greater attentional avoidance of sad faces. This attention bias was specific to sad, rather than happy or angry, faces. There was also preliminary evidence that this relation is stronger among children carrying the 5-HTTLPR S or LG allele than among those homozygous for the LA allele. Next, conceptualizing mothers’ levels of depressive symptoms during the multi-wave prospective follow-up within a vulnerability-stress framework, we found evidence for a three-way child 5-HTTLPR × attentional bias × mother depressive symptom interaction predicting children’s depressive symptoms. Specifically, the relation between mother and child depressive symptom levels over time was strongest among children carrying the 5-HTTLPR S or LG allele who also exhibited attentional avoidance of sad faces. These findings provide initial support for role of children’s 5-HTTLPR genotype and attentional biases for sad faces in the intergenerational transmission of depression.