Chlamydia and Its Many Ways of Escaping the Host Immune System.
Chlamydia and Its Many Ways of Escaping the Host Immune System.
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衣原体及其逃避宿主免疫系统的多种方法。
DOI：
10.1155/2019/8604958
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发表时间：
2019
影响因子：
2.6
通讯作者：
Arulanandam,BernardP
中科院分区：
文献类型：
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作者：
Wong,WonFen;Chambers,JamesP;Gupta,Rishein;Arulanandam,BernardP
全球衣原体感染新病例数量的增加可能归因于病原体逃避各种宿主免疫反应的能力。这里总结了衣原体利用的逃避方法，使其能够在敌对的宿主环境中生存。病原体的持续存在涉及以多种方式表现的无数分子相互作用，例如，膜胞质内包涵体的形成和细胞因子诱导的氨基酸合成、吞噬中性粒细胞的麻痹、吞噬作用的逃避、宿主细胞凋亡的抑制、抗原呈递的抑制以及检查的诱导表达 程序性宿主细胞死亡的点抑制剂。未来的研究可能集中于这些与免疫逃避相关的分子的靶向，从而限制这种病原体引起的传播和组织损伤。
The increasing number of new cases ofChlamydiainfection worldwide may be attributed to the pathogen’s ability to evade various host immune responses. Summarized here are means of evasion utilized byChlamydiaenabling survival in a hostile host environment. The pathogen′s persistence involves a myriad of molecular interactions manifested in a variety of ways,e.g., formation of membranous intracytoplasmic inclusions and cytokine‐induced amino acid synthesis, paralysis of phagocytic neutrophils, evasion of phagocytosis, inhibition of host cell apoptosis, suppression of antigen presentation, and induced expression of a check point inhibitor of programmed host cell death. Future studies could focus on the targeting of these molecules associated with immune evasion, thus limiting the spread and tissue damage caused by this pathogen.