Abnormal distribution of Fc gamma receptor type IIa polymorphisms in Korean patients with systemic lupus erythematosus.
Abnormal distribution of Fc gamma receptor type IIa polymorphisms in Korean patients with systemic lupus erythematosus.
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DOI：
10.1002/1529-0131(199803)41:3
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发表时间：
1998-03
影响因子：
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通讯作者：
Y. W. Song;Y. W. Song;Chang Wan Han;Seong Wook Kang;Han Joo Baek;Eun Bong Lee;Chang H.O. Shin;B. Hahn;B. Tsao
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文献类型：
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作者：
Y. W. Song;Y. W. Song;Chang Wan Han;Seong Wook Kang;Han Joo Baek;Eun Bong Lee;Chang H.O. Shin;B. Hahn;B. Tsao
目的 免疫复合物清除异常是系统性红斑狼疮 (SLE) 的一个特征。 Fc gamma 受体 IIa 型 (Fc gammaRIIa) 基因（受体结合 IgG2 和 IgG3）的多态性是某些人群中重要的疾病易感因素。本研究旨在确定这些多态性对韩国 SLE 患者的影响。方法 采用基因组 DNA 聚合酶链反应和等位基因特异性寡核苷酸杂交来确定韩国 SLE 患者和健康对照受试者的 Fc gammaRIIa 基因型。分析每位患者的临床表现并与基因型相关。结果 在 73 名 SLE 患者中，与 64 名对照相比，Fc gammaRIIa 等位基因分布异常：11.0% 的 SLE 患者为 Fc gammaRIIa-H131 纯合子，而对照组为 34.4%（比值比 [OR] 0.20，95% 置信区间 [95% CI] 0.04-0.95，chi2 = 5.7，P = 0.01699）。 SLE 患者中 Fc gammaRIIa-H131 等位基因频率显着低于对照组（49.3% vs 63.3%；P = 0.02019），狼疮肾炎患者中 Fc gammaRIIa-H131 等位基因频率也显着低于正常人群（OR 0.53，95% CI 0.29-0.95，chi2 = 5.15，P = 0.02330），但在无肾炎的狼疮患者中并没有显着降低（与对照组相比，P = 0.13663）。临床上，R/R131的狼疮性肾炎患者的蛋白尿水平显着高于H/H131或R/H131的狼疮肾炎患者。结论 Fc gammaRIIa 多态性分布异常与韩国患者的 SLE 相关。 SLE 患者（尤其是肾炎患者）的 Fc gammaRIIa-H/H131 基因型和 H131 等位基因频率显着下降。这表明 H131 等位基因对该人群具有一定的 SLE 保护作用。
OBJECTIVE Abnormal immune complex clearance is a feature of systemic lupus erythematosus (SLE). Polymorphisms of the Fc gamma receptor type IIa (Fc gammaRIIa) genes (the receptor binds IgG2 and IgG3) are important disease susceptibility factors in some populations. This study sought to determine the effects of these polymorphisms among Korean patients with SLE. METHODS Polymerase chain reaction of genomic DNA and allele-specific oligonucleotide hybridization were used to determine Fc gammaRIIa genotypes in Korean patients with SLE and healthy control subjects. Clinical manifestations were analyzed in each patient and correlated with the genotypes. RESULTS Among the 73 SLE patients, there was an abnormal distribution of Fc gammaRIIa alleles when compared with 64 controls: 11.0% of the SLE patients were homozygous for Fc gammaRIIa-H131 compared with 34.4% of the controls (odds ratio [OR] 0.20, 95% confidence interval [95% CI] 0.04-0.95, chi2 = 5.7, P = 0.01699). The allelic frequency of Fc gammaRIIa-H131 was significantly lower in the SLE patients than in the controls (49.3% versus 63.3%; P = 0.02019), and it was also significantly lower in lupus patients with nephritis compared with the normal population (OR 0.53, 95% CI 0.29-0.95, chi2 = 5.15, P = 0.02330), but was not significantly lower in lupus patients without nephritis (P = 0.13663 versus controls). Clinically, the level of proteinuria was significantly higher in the lupus nephritis patients who had R/R131 than in those who had H/H131 or R/H131. CONCLUSION An abnormal distribution of Fc gammaRIIa polymorphisms was associated with SLE in Korean patients. There was a significant decrease in the Fc gammaRIIa-H/H131 genotype and H131 allelic frequency in SLE patients, particularly in those with nephritis. This suggests that the H131 allele confers some protection from SLE in this population.