EVALUATION OF HEMOLYTIC ROLE OF ASPIRIN IN GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY
EVALUATION OF HEMOLYTIC ROLE OF ASPIRIN IN GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY
复制标题
DOI：
10.1016/s0022-3476(76)80626-9
复制
发表时间：
1976-01-01
影响因子：
5.1
通讯作者：
GLADER, BE
中科院分区：
文献类型：
--
作者：
GLADER, BE
在葡萄糖-6-磷酸脱氢酶[G-6-PD]缺乏的健康患者中检测阿司匹林的溶血作用，并在正常和G-6-PD缺乏的红细胞中测定水杨酸盐及其1种氧化代谢物龙胆酸的体外作用。以前有人认为阿司匹林的溶血性是由龙胆酸引起的，但引起溶血所需的浓度高于正常治疗条件。阿司匹林相关溶血可能由相关临床问题引起，即，感染，而不是药物管理。阿司匹林可能可以安全地用于临床指征为G-6-PD缺乏症的患者。
The hemolytic role of aspirin was examined in healthy patients with glucose-6-phosphate dehydrogenase [G-6-PD] deficiency, and the in vitro effects of salicylate and its 1 oxidant metabolite, gentisic acid, were measured in normal and G-6-PD-deficient red blood cells. It was previously suggested that the hemolytic properties of aspirin were caused by gentisic acid, but the concentration needed to cause hemolysis is above normal therapeutic conditions. Aspirin related hemolysis may be caused by associated clinical problems, i.e., infection, rather than drug administration. Aspirin can probably be safely used for conditions where it is clinically indicated in patients with G-6-PD deficiency.