Patterns and risk factors associated with aromatase inhibitor-related arthralgia among breast cancer survivors.
Patterns and risk factors associated with aromatase inhibitor-related arthralgia among breast cancer survivors.
复制标题
乳腺癌幸存者中与芳香酶抑制剂相关的关节痛的模式和危险因素。
DOI：
10.1002/cncr.24419
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发表时间：
2009-08-15
期刊：
影响因子：
6.2
通讯作者：
DeMichele A
中科院分区：
文献类型：
--
作者：
Mao JJ;Stricker C;Bruner D;Xie S;Bowman MA;Farrar JT;Greene BT;DeMichele A
关节痛在接受芳香酶抑制剂(AI)治疗的绝经后乳腺癌幸存者(BC)中很常见。本研究旨在评估AI相关关节痛(AIA)的发病、特征和危险因素。我们在一所大学的肿瘤诊所对接受辅助人工智能治疗的绝经后BCS进行了横断面调查。患者报告的AIS归因是关节疼痛的一个原因被用作主要结果。对危险因素(S)进行多因素Logistic回归分析。在300名参与者中，139人(47%)认为人工智能是他们目前关节痛的原因之一。在这些患者中，74%的患者在服药后三个月内认识到AIA的发病，67%的患者在之前的七天内被评为中度或重度关节疼痛。在MVA中，自上次月经期(LMP)以来的时间是唯一有意义的预测AIA的因素。控制协变量，LMP在5年内发生AIA的概率最高(73%)，而LMP在10年以上者最低(35%；调整优势比3.39，95%可信区间1.21-9.44，P=0.02)。与非人工智能相关的关节症状相比，手腕/手、脚踝/脚、肘部和膝盖与人工智能相关症状的相关性似乎更强(均P<；0.01)。AIA很常见，大多数患者在治疗的前三个月内就开始了，而且似乎与月经功能停止的时间长短成反比。这些发现表明，雌激素停用可能在这种疾病的机制中发挥了作用。
Arthralgia is common in postmenopausal breast cancer survivors (BCS) receiving aromatase inhibitors (AI). This study aims to evaluate the perceived onset, characteristics, and risk factors for AI-related arthralgia (AIA). We performed a cross-sectional survey of postmenopausal BCS receiving adjuvant AI therapy at a university-based oncology clinic. Patient-reported attribution of AIs as a cause of joint pain was used as the primary outcome. Multivariate logistic regression analyses (MVA) were performed to evaluate risk factor(s). Among 300 participants, 139 (47%) attributed AI as a cause of their current arthralgia. Of these patients, 74% recognized onset of AIA within three months since medication initiation, and 67% rated joint pain moderate or severe in the previous seven days. In a MVA, time since last menstrual period (LMP) was the only significant predictor of AIA. Controlling for covariates, those who had LMP within five years had the highest probability of reporting AIA (73%), while those with LMP beyond ten years had the lowest (35%; adjusted odds radio, 3.39, 95% confidence interval, 1.21-9.44, P=0.02). Wrists/hands, ankles/feet, elbows and knees appeared to be more strongly associated with AI-related symptoms than non-AI related joint symptoms (all p<0.01). AIA is common, begins within the first three months of therapy in most patients, and appears to be inversely related to the length of time since cessation of menstrual function. These findings suggest that estrogen withdrawal may play a role in the mechanism of this disorder.
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影响因子：
45.3
作者：
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