Copper(II)-catalyzed C–H (sp3) oxidation and C–N cleavage: synthesis of methylene-bridged compounds using TMEDA as a carbon source in water
Copper(II)-catalyzed C–H (sp3) oxidation and C–N cleavage: synthesis of methylene-bridged compounds using TMEDA as a carbon source in water
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DOI：
10.1039/c3ra40695d
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发表时间：
2013-06
期刊：
影响因子：
3.9
通讯作者：
Dan Zhao;Yue Wang;Min-Xue Zhu;Qi Shen;Lei Zhang;Yun Du;Jian-Xin Li
中科院分区：
文献类型：
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作者：
Dan Zhao;Yue Wang;Min-Xue Zhu;Qi Shen;Lei Zhang;Yun Du;Jian-Xin Li
以四亚甲二胺（TMEDA）为碳源，通过CuCl2/氧介导的C-H （sp3）氧化和C-N裂解，建立了一种绿色、简单、高效的选择性甲基化方案。在常压条件下，在绿色溶剂水中进行反应。该方案显示了广泛的底物范围，包括吲哚，苯胺，吡咯和1,3-二羰基。此外，成功鉴定了反应的两个关键中间体，并对反应机理进行了探讨。
A green, simple, and efficient protocol for the selective methylenation via CuCl2/oxygen-mediated C–H (sp3) oxidation and C–N cleavage using tetramethylethylenediamine (TMEDA) as a carbon source has been developed. The reactions were achieved in green solvent water under atmospheric conditions. The protocol exhibited a broad substrate scope including indoles, anilines, pyrroles and 1,3-dicarbonyls. Furthermore, two key intermediates of the reaction were successfully identified and the mechanism was explored.