Application of LHRH analogues in treatment of ovarian cancer
Application of LHRH analogues in treatment of ovarian cancer
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发表时间：
2003
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通讯作者：
C. Ying
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作者：
C. Ying
卵巢癌是一种激素依赖性癌症。LHRH类似物不仅通过抑制下丘脑-垂体-性腺轴发挥抗卵巢癌作用，而且通过激活卵巢癌细胞的LHRH受体直接抑制细胞增殖和诱导细胞凋亡。另外，靶向于肿瘤细胞上LHRH受体的LHRH类似物可以携带细胞毒性药物，从而这些靶向细胞毒性LHRH类似物导致更高的疗效和更小的毒性作用。总之，LHRH类似物治疗顽固性卵巢癌可能是一种有价值的选择。
Ovarian cancer is a kind of hormone dependent cancer. LHRH analogues not only present antitumor effects on ovarian cancer by suppressing the hypothalamus pituitary gonadal axis, but also directly inhibit the proliferation and induce the apoptosis through LHRH receptors activated by ovarian carcinoma cell. In addition, LHRH analogues targeting to LHRH receptors on the tumor cell can carry cytotoxic agents, and then these targeting cytotoxic LHRH analogues result in more curative effect and less toxic effect. In a word, treatment with LHRH analogues may be a valuable alternative for obstinate ovarian cancer.