A 14-year nationwide epidemiological analysis of delayed endolymphatic hydrops in Japan
A 14-year nationwide epidemiological analysis of delayed endolymphatic hydrops in Japan
复制标题
日本14年迟发性内淋巴积水全国流行病学分析
DOI：
10.1080/00016489.2022.2108141
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发表时间：
2022
影响因子：
1.4
通讯作者：
Omori Koichi et al.
中科院分区：
文献类型：
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作者：
Ito Shinsuke;Takakura Hiromasa;Akaogi Katsuichi;Shojaku Hideo;Takeda Noriaki;Suzuki Mamoru;Watanabe Yukio;Aoki Mitsuhiro;Doi Katsumi;Ikezono Tetsuo;Kakigi Akinobu;Kitahara Tadashi;Koizuka Izumi;Murofushi Toshihisa;Naganuma Hideaki;Omori Koichi et al.
背景迟发性内淋巴积水（delayed endlymphatic hydrops，DEH）是一种因继发于耳聋的内淋巴积水而引起的同侧耳反复眩晕或对侧耳听力波动的内耳疾病。很少有大型的，多中心的研究调查的临床流行病学特征的DEH. ESTA研究旨在澄清的特点，在日本的DEH.MethodsClinical数据662例患者进行了分析，结果同侧DEH（IDEH）的发生率略高于对侧DEH（CDEH）; 55.4%。CDEH组从既往耳聋发作到DEH发作的时间延迟明显长于IDEH组。最常见的先天性耳聋的原因是一种不明原因的疾病，在儿童早期发病（33.1%）。流行病学特征之间没有显着差异CDEH和没有vertighty.ConclusionDEH出现病毒性中耳炎引起的发病率高，在40年内的先例耳聋。IDEH、伴有眩晕的CDEH和不伴有眩晕的CDEH的临床和流行病学特征非常相似。
BackgroundDelayed endolymphatic hydrops (DEH) is an inner ear disease that causes recurrent vertigo in the ipsilateral ear or fluctuating hearing in the contralateral ear due to endolymphatic hydrops secondary to preceding deafness. There are few reports of large, multicentre studies investigating the clinical-epidemiological characteristics of DEH.ObjectiveThis study aimed to clarify the characteristics of DEH in Japan.MethodsClinical data on 662 patients with DEH were analysed by nationwide, multicentre surveys conducted by the Peripheral Vestibular Disorders Research Group of Japan.ResultsThe proportion of ipsilateral DEH (IDEH) was slightly higher than that of contralateral DEH (CDEH) at 55.4%. The time delay between onset of precedent deafness and onset of DEH was significantly longer for CDEH than for IDEH. The most common cause of precedent deafness was a disease of unknown cause with onset in early childhood (33.1%). Epidemiological characteristics were not significantly different between CDEH with and without vertigo.ConclusionDEH appearing to be caused by viral labyrinthitis has a high rate of onset within 40 years of precedent deafness. Clinical and epidemiological characteristics of IDEH, CDEH with vertigo, and CDEH without vertigo were very similar.SignificanceThe clinical-epidemiological characteristics of DEH in Japan were clarified.