Combination therapy with vitamin D analogues
Combination therapy with vitamin D analogues
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与维生素 D 类似物的联合治疗
DOI：
10.1046/j.1365-2133.2001.144s58027.x
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发表时间：
2001
影响因子：
10.3
通讯作者：
M. Lebwohl
中科院分区：
文献类型：
--
作者：
S. Lamba;M. Lebwohl
维生素D类似物的单药治疗已被证明是有效的治疗银屑病。维生素D类似物也与其他局部疗法、全身疗法和光疗联合使用。在许多情况下，当与维生素D类似物组合时，这些其他治疗的功效可以最大化，副作用最小化。局部皮质类固醇与维生素D类似物的组合可以协同作用，以提高疗效并减少两种治疗的副作用。然而，混合两种药物时必须谨慎，因为某些局部皮质类固醇会导致维生素D类似物降解。当使用维生素D类似物时，光疗的益处也会增加，因此治疗越少，改善越大。必须考虑对最小红斑剂量的影响，维生素D类似物阻断紫外线的可能性可能会影响治疗。一些维生素D类似物也可能容易被某些波长的紫外光降解。将维生素D类似物与全身性药物联合使用可发挥剂量节省作用，从而降低副作用的可能性，但此类组合需要进一步研究。只要正确使用治疗方法，与维生素D类似物联合治疗的好处通常超过少数缺点。
Monotherapy with vitamin D analogues has been shown to be effective in the treatment of psoriasis. Vitamin D analogues have also been used in combination with other topical therapies, systemic therapies and phototherapy. In many instances, the efficacy of these other treatments can be maximized and adverse effects minimized when combined with vitamin D analogues. The combination of a topical corticosteroid with a vitamin D analogue can work synergistically to improve efficacy and reduce the side‐effects from both treatments. However, caution must be used when mixing the two agents, as some topical corticosteroids will result in the degradation of the vitamin D analogue. Benefit from phototherapy is also increased when using vitamin D analogues, so that greater improvement occurs with fewer treatments. Effects on minimal erythema dose must be considered and the potential for ultraviolet blocking by vitamin D analogues may affect treatment. Some vitamin D analogues may also be susceptible to degradation by certain wavelengths of ultraviolet light. Combining vitamin D analogues with systemic agents exerts a dose‐sparing effect, thus reducing the possibility of side‐effects, but such combinations require further study. As long as treatments are used correctly, the benefits of combination therapy with vitamin D analogues usually outweigh the few drawbacks.