Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry
Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry
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DOI：
10.1039/d0cc00266f
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发表时间：
2020-03-25
影响因子：
4.9
通讯作者：
Hargrove, Amanda E.
中科院分区：
文献类型：
--
作者：
Juru, Umuhire Aline;Cai, Zhengguo;Hargrove, Amanda E.
本研究建立了基于亚胺的动态组合化学的适用性，发现RNA靶的非共价配体。我们阐明了芳基胺的反应性的基本属性，并证明了在基于阿米洛利的动态库中的紧密结合物的靶向扩增。
This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.