Domino Michael/Michael reaction catalyzed by switchable modularly designed organocatalysts
Domino Michael/Michael reaction catalyzed by switchable modularly designed organocatalysts
复制标题
可切换模块化设计的有机催化剂催化多米诺迈克尔/迈克尔反应
DOI：
10.1039/d1ob01991k
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发表时间：
2021
影响因子：
3.2
通讯作者：
Zhao, John C.-G.
中科院分区：
文献类型：
--
作者：
Parella, Ramarao;Jakkampudi, Satish;Bora, Pranjal;Sakkani, Nagaraju;Zhao, John C.-G.
用模块化设计的有机催化剂(MDO)研究了(E)-7-芳基-7-氧杂环己烯-5-烯醛与反式肉桂醛之间的多米诺Michael/Michael反应。研究发现，MDOS的烯胺和亚胺催化模式都是可切换的，并且可以通过适当的预催化剂模块和反应条件的组合来单独开启和关闭。当MDOS的烯胺和亚胺两种催化模式同时开启时，在优化的条件下，可以以良好的产率和立体选择性获得所需的多米诺反应产物。
The domino Michael/Michael reaction between (E)-7-aryl-7-oxohept-5-enals and trans-cinnamaldehydes was investigated by using modularly designed organocatalysts (MDOs). It was found that both the enamine and iminium catalytic modes of the MDOs are switchable and can be individually switched on and off by using appropriate combinations of the precatalyst modules and the reaction conditions. When both the enamine and iminium catalysis modes of the MDOs are switched on, the desired domino reaction products can be obtained in good yields and stereoselectivities under optimized conditions.