Electron transfer/ion transfer mode of scanning electrochemical microscopy (SECM): a new tool for imaging and kinetic studies
Electron transfer/ion transfer mode of scanning electrochemical microscopy (SECM): a new tool for imaging and kinetic studies
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扫描电化学显微镜（SECM）的电子转移/离子转移模式：成像和动力学研究的新工具
DOI：
10.1039/c3sc50825k
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发表时间：
2013
期刊：
影响因子：
8.4
通讯作者：
M. Mirkin
中科院分区：
文献类型：
--
作者：
Yixian Wang;K. Kececi;J. Velmurugan;M. Mirkin
开发了一种新的扫描电化学显微镜（SECM）操作模式，该模式将纳米移液器的试剂输送与导电基板上的电子转移以及纳米移液器尖端支持的液/液界面上的离子转移结合起来。这种方法通过直接分离表面形貌和反应特征对尖端电流的贡献，为异质电子转移动力学和反应速率成像的测量提供了潜在的优势。它解决了其他一些长期存在的技术问题，包括在没有扩散展宽的情况下对低信号源（例如固定酶或催化剂颗粒）进行灵敏探测，以及消除生成/收集型实验中升高的背景信号。电子转移/离子转移模式实验中可获得的高空间分辨率以及本体溶液中不存在氧化还原介体物质对于生物细胞的研究是有利的。
A new mode of the scanning electrochemical microscope (SECM) operation was developed that combines reagent delivery from the nanopipette with electron transfer at the conductive substrate and ion transfer across the liquid/liquid interface supported at the nanopipette tip. This approach offers potential advantages for measurements of heterogeneous electron transfer kinetics and reaction rate imaging by enabling straightforward separation of the contributions of surface topography and reactivity features to the tip current. It addresses some other long-standing technical issues, including sensitive probing of low signal sources (e.g., immobilized enzymes or catalyst particles) without diffusional broadening and the elimination of the elevated background signal in generation/collection-type experiments. The high spatial resolution attainable in electron transfer/ion transfer mode experiments and the absence of redox mediator species in the bulk solution are advantageous for studies of biological cells.