Prenatal toxicity, maternal distribution and placental transfer of tetrahydrocannabinol.
Prenatal toxicity, maternal distribution and placental transfer of tetrahydrocannabinol.
复制标题
四氢大麻酚的产前毒性、母体分布和胎盘转移。
DOI：
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发表时间：
1972
影响因子：
3.5
通讯作者：
B. Mantilla
中科院分区：
文献类型：
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作者：
R. Harbison;B. Mantilla
Δ 9 -四氢大麻酚（Δ 9 - thc）对怀孕的小鼠具有胚胎或胎儿杀死作用。Δ 9 -四氢大麻酚在妊娠第8天和第9天使用产生约70%的宫内死亡发生率。Δ 9 -四氢大麻酚在妊娠第10天和第11天或第12天和第13天使用时，导致约30%的子宫内死亡率。Δ 9 -THC还能显著降低胎儿体重。再说一次，这是妊娠期的易感性。经腹腔注射14c标记的Δ 9 -THC后，测定母体血浆中14c的含量。在母体脂肪和肝组织中发现了更多的14c积累。在母体肾脏、肌肉和脑组织中检测到少量的14c。Δ 9 -四氢大麻酚通过胎盘转移，并在胎儿组织和羊水中测量。Δ 9 -四氢大麻酚主要通过粪便排出，注射后120小时约有10%的剂量残留在动物体内。尿液中Δ 9 -四氢大麻酚的最大排泄量约为给药剂量的10%。因此，Δ 9 -四氢大麻酚通过胎盘转移，是杀胚胎或杀胎儿的。
Δ 9 -Tetrahydrocannabinol (Δ 9 -THC) was embryo- or fetocidal when administered to pregnant mice. Δ 9 -THC administered on days 8 and 9 of gestation produced about 70% incidence of in utero deaths. Δ 9 -THC induced about 30% incidence of in utero deaths when administered on gestational days 10 and 11 or days 12 and 13. Δ 9 -THC also significantly reduced fetal body weight. Again, there was a gestational period susceptibility. After i.p. administration of 14 C-labeled Δ 9 -THC, 14 C was measured in maternal plasma. The greater accumulation of 14 C was found in maternal fat and liver tissue. Smaller amounts of 14 C were measured in maternal kidney, muscle and brain tissue. Δ 9 -THC was transferred across the placenta and was measured in fetal tissue and amnionic fluid. Excretion of Δ 9 -THC was primarily by feces and at 120 hours after injection about 10% of the dose remained in the animals. Maximum excretion of Δ 9 -THC in the urine was about 10% of the administered dose. Thus, Δ 9 -THC is transferred across the placenta and is embryocidal or fetocidal.