THE EMERGENCE OF THE CHAPERONE MACHINES
THE EMERGENCE OF THE CHAPERONE MACHINES
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DOI：
10.1016/0968-0004(92)90439-g
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发表时间：
1992-08-01
影响因子：
13.8
通讯作者：
GEORGOPOULOS, C
中科院分区：
文献类型：
--
作者：
GEORGOPOULOS, C
为了确保适当的多肽折叠、寡聚化和运输，复杂的分子“伴侣机器”已经进化出来。这些机器通常由一种主要的伴侣蛋白和一组伴侣蛋白“群”组成，这种蛋白质可以混杂地与新生的、未折叠的、错误折叠的或聚集的多肽结合，其功能是提高效率并确保循环利用。这些伴侣机器可以自己运作或协同执行各种任务。
To ensure proper polypeptide folding, oligomerization and transport, elaborate molecular 'chaperone machines' have evolved. These machines are usually composed of a major chaperone protein that binds promiscuously to nascent, unfolded, misfolded or aggregated polypeptides and a set of chaperone 'cohorts', whose function is to enhance efficiency and ensure recycling. These chaperone machines can function by themselves or synergistically to carry out their various tasks.