Neurological and Epigenetic Implications of Nutritional Deficiencies on Psychopathology: Conceptualization and Review of Evidence.
Neurological and Epigenetic Implications of Nutritional Deficiencies on Psychopathology: Conceptualization and Review of Evidence.
复制标题
营养缺乏对心理病理学的神经和表观遗传学意义：证据的概念化和回顾。
DOI：
10.3390/ijms160818129
复制
发表时间：
2015-08-05
影响因子：
5.6
通讯作者：
Reyes T
中科院分区：
文献类型：
--
作者：
Liu J;Zhao SR;Reyes T
近年来，表观遗传修饰在疾病病理生理学中的作用受到了极大的关注。许多研究现在开始探索基因-环境相互作用，这可能介导早期生活暴露于风险因素，如营养缺乏和儿童和成人后期行为问题的发展。在本文中，我们回顾了目前的文献表观遗传学在精神病理学的发展中的作用，特别关注表观遗传修饰的潜力，以联系营养和大脑发育。我们提出了一个概念框架，表观遗传修饰（例如，DNA甲基化）介导生命早期微量和大量营养素缺乏与脑功能障碍之间的联系（例如，结构畸变、神经递质干扰），这与以后生活中行为问题的发展有关。
In recent years, a role for epigenetic modifications in the pathophysiology of disease has received significant attention. Many studies are now beginning to explore the gene–environment interactions, which may mediate early-life exposure to risk factors, such as nutritional deficiencies and later development of behavioral problems in children and adults. In this paper, we review the current literature on the role of epigenetics in the development of psychopathology, with a specific focus on the potential for epigenetic modifications to link nutrition and brain development. We propose a conceptual framework whereby epigenetic modifications (e.g., DNA methylation) mediate the link between micro- and macro-nutrient deficiency early in life and brain dysfunction (e.g., structural aberration, neurotransmitter perturbation), which has been linked to development of behavior problems later on in life.