Relationship between biochemical markers and measles viral load in patients with immunologically naive cases and secondary vaccine failure: LDH is one of the potential auxiliary indicators for secondary vaccine failure
Relationship between biochemical markers and measles viral load in patients with immunologically naive cases and secondary vaccine failure: LDH is one of the potential auxiliary indicators for secondary vaccine failure
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DOI：
10.1111/1348-0421.12891
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发表时间：
2021-06-29
影响因子：
2.6
通讯作者：
Motomura, Kazushi
中科院分区：
文献类型：
--
作者：
Kurata, Takako;Kanbayashi, Daiki;Motomura, Kazushi
本研究对38例麻疹患者的血清生化指标与病毒载量的相关性进行了研究，其中包括15例免疫初治者和23例继发性疫苗失败(SVF)患者。我们检测了天冬氨酸氨基转移酶、丙氨酸氨基转移酶、C反应蛋白和乳酸脱氢酶四种生化标志物及其与外周血单个核细胞(PBMC)和咽拭子中病毒基因组拷贝数以及麻疹特异性免疫球蛋白(IgG)浓度的关系。虽然两种临床标本中的病毒基因组拷贝数与特异性免疫球蛋白浓度显著相关，但在PBMC中的相关性(皮尔逊积矩相关系数为-0.662；p<；0.0001)高于咽拭子中的相关性(Spearman‘s等级相关系数为-0.443；p=0.0078)。PBMC中的病毒载量与LDH值也显著相关(相关系数为0.360；p=.036)。因此，血清LDH水平可能是鉴别免疫初治麻疹患者和SVF患者的一个潜在的辅助指标。
This study investigated the correlation between biochemical markers and viral load among 38 measles cases, including 15 immunologically naive patients and 23 patients with secondary vaccine failure (SVF). We examined four biochemical markers, namely, aspartate aminotransferase, alanine aminotransferase, C-reactive protein, and lactate dehydrogenase (LDH) and their relationship between virus genome copy numbers in peripheral blood mononuclear cells (PBMCs) and throat swabs as well as the concentration of measles-specific IgG. Although viral genome copies in both clinical specimens showed a significant correlation with specific IgG concentration, they had a higher correlation in PBMCs (Pearson's product-moment correlation coefficient, -0.662; p < .0001) than in throat swabs (Spearman's rank correlation coefficient, -0.443; p = .0078). The viral load in PBMCs also significantly correlated with LDH values (correlation coefficient, 0.360; p = .036). Thus, the serum LDH level might be a potential auxiliary indicator to distinguish immunologically naive patients with measles from those with SVF.