Epithelial morphogenesis in mouse embryonic submandibular gland: Its relationships to the tissue organization of epithelium and mesenchyme
Epithelial morphogenesis in mouse embryonic submandibular gland: Its relationships to the tissue organization of epithelium and mesenchyme
复制标题
小鼠胚胎颌下腺上皮形态发生：其与上皮和间质组织的关系
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Y. Nakanishi
中科院分区：
文献类型：
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作者：
Y. Hieda;Y. Nakanishi
各种器官雏形中的上皮组织在其发育过程中经历广泛的形状变化。上皮形状变化的过程由组织与周围间充质的相互作用控制，所述间充质与上皮保持直接接触。已被广泛研究的器官之一是小鼠胚胎下颌下腺，其上皮显示出特征性的分支形态发生，开始形成狭窄而深的裂缝以及组织结构的变化。间充质中的各种分子，包括生长因子和细胞外基质成分，影响上皮形状和组织结构的变化。此外，间充质组织表现出动态特性，例如成组的定向运动和胶原纤维的重排，以及间充质细胞产生的力。在早期分支形态发生期间，上皮形成细胞团，其中细胞-细胞粘附系统不太发达。间充质和上皮的这些性质对于考虑裂缝是如何形成和稳定的是重要的，裂缝最初表现为上皮表面上不稳定的微小凹陷。
Epithelial tissues in various organ rudiments undergo extensive shape changes during their development. The processes of epithelial shape change are controlled by tissue interactions with the surrounding mesenchyme which is kept in direct contact with the epithelium. One of the organs which has been extensively studied is the mouse embryonic submandibular gland, whose epithelium shows the characteristic branching morphogenesis beginning with the formation of narrow and deep clefts as well as changes in tissue organization. Various molecules in the mesenchyme, including growth factors and extracellular matrix components, affect changes of epithelial shape and tissue organization. Also, mesenchymal tissue exhibits dynamic properties such as directional movements in groups and rearrangement of collagen fibers coupled with force‐generation by mesenchymal cells. The epithelium, during early branching morphogenesis, makes a cell mass where cell‐cell adhesion systems are less developed. Such properties of both the mesenchyme and epithelium are significant for considering how clefts, which first appear as unstable tiny indentations on epithelial surfaces, are formed and stabilized.
乳胶珠和视网膜色素上皮细胞沿腹侧神经嵴通路的分布。
影响因子：
2.7
作者：
Bronner-Fraser,M
通讯作者：
Bronner-Fraser,M