Effectiveness and limitation of gamma knife radiosurgery for relapsed central nervous system lymphoma: A retrospective analysis in one institution
Effectiveness and limitation of gamma knife radiosurgery for relapsed central nervous system lymphoma: A retrospective analysis in one institution
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DOI：
10.1532/ijh97.06205
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发表时间：
2007-05-01
影响因子：
2.1
通讯作者：
Taniwaki, Masafumi
中科院分区：
文献类型：
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作者：
Matsumoto, Yosuke;Horiike, Shigeo;Taniwaki, Masafumi
我们描述了6例复发性中枢神经系统淋巴瘤（CNSL）的伽玛刀治疗（GKR）。所有6例患者的组织学诊断均为弥漫性大B细胞淋巴瘤，无人类免疫缺陷病毒感染。2例患者发生原发性CNSL颅内复发，其余4例患者发生系统性淋巴瘤CNS复发。所有患者均接受GKR治疗，无严重不良反应，除1例患者外，所有患者均在GKR后不久接受后续化疗。4例患者显示完全缓解，其余2例患者部分缓解或病情稳定。虽然所有患者的神经系统症状消失或明显改善，但所有疾病均在首次GKR后3 ~ 13个月复发或进展。最终在4例患者中进行了第二次GKR。首次GKR后的中位总生存期和无进展生存期分别为47个月和11个月。根据我们的经验，GKR似乎是治疗复发性CNSL的一种有用的方法，因为它有助于在短期治疗期间获得良好的局部控制，没有严重的并发症，尽管疗效期不够长。
We describe 6 patients with relapsed central nervous system lymphoma (CNSL) treated with Gamma Knife radiosurgery (GKR). The histologic diagnosis in all 6 patients was diffuse large B-cell lymphoma without human immunodeficiency virus infection. Two patients had intracranial relapse of primary CNSL, and the remaining 4 had CNS relapse of systemic lymphoma. All patients were treated with GKR without severe adverse effects, and all but 1 patient received subsequent chemotherapy shortly after GKR. Four patients showed a complete response, and the remaining 2 patients had a partial response or stable disease. Although the neurologic symptoms disappeared or improved markedly in all patients, all of the diseases recurred or progressed 3 to 13 months after the first GKR. A second GKR was eventually performed in 4 patients. The median overall survival and progression-free survival times after the first GKR were 47 and 11 months, respectively. In our experience, GKR seems to be a useful procedure for the treatment of relapsed CNSL, because it facilitates excellent local control in a short-term treatment period without severe complications, although the efficacy period is not long enough.