Chromones from the Endophytic Fungus Pestalotiopsis sp Isolated from the Chinese Mangrove Plant Rhizophora mucronata
Chromones from the Endophytic Fungus Pestalotiopsis sp Isolated from the Chinese Mangrove Plant Rhizophora mucronata
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DOI：
10.1021/np800748u
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发表时间：
2009-04-01
影响因子：
5.1
通讯作者：
Proksch, Peter
中科院分区：
文献类型：
--
作者：
Xu, Jing;Kjer, Julia;Proksch, Peter
从红树林内生真菌拟盘多毛孢（Pestalotiopsissp.）的菌丝体和培养滤液中分离得到6个新的色酮化合物，命名为pestalotiopsones A-F（1-6）和已知衍生物7-羟基-2-（2-羟丙基）-5-甲基色酮（7），其分离自中国红树林植物Rhizophora mucronata的叶子。根据光谱数据鉴定了它们的结构。Pestalotiopsone A-F是具有在C-2处取代的烷基侧链和在C-5处的游离或取代的羧基的色酮。化合物6对鼠癌细胞系L5178 Y表现出中等的细胞毒性，而其他研究的化合物被证明是无活性的。
Six new chromones, named pestalotiopsones A-F (1-6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pestalotiopsis sp., which was isolated from leaves of the Chinese Mangrove plant Rhizophora mucronata. Their structures were elucidated on the basis of spectroscopic data. Pestalotiopsones A-F are chromones having both an alkyl side chain substituted at C-2 and a free or substituted carboxyl group at C-5. Compound 6 exhibited moderate cytotoxicity against the murine cancer cell line L5178Y, whereas the other investigated compounds proved to be inactive.