MORPHOLOGICAL MANIFESTATIONS OF REPERFUSION INJURY IN BRAIN
MORPHOLOGICAL MANIFESTATIONS OF REPERFUSION INJURY IN BRAIN
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DOI：
10.1111/j.1749-6632.1994.tb36713.x
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发表时间：
1994-01-01
期刊：
影响因子：
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通讯作者：
DIETRICH, WD
中科院分区：
文献类型：
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作者：
DIETRICH, WD
再灌注损伤被认为是缺血引起的脑疾病的一个重要方面。随着临床相关的脑卒中和脑血管损伤动物模型的不断完善，脑缺血再灌注损伤的研究将获得更直接的证据。实验研究应考虑哪些结果指标与临床最相关，并利用慢性组织病理学和行为评估来监测结果。最近的数据表明，脑损伤的微血管和细胞反应是一个复杂的和时间依赖性的序列。在不同的再灌注期发生的病理生理事件的可能性表明，可能存在多个治疗窗口的脑保护。因此，可以想象，成功的治疗策略可能最终涉及针对再灌注早期、中期和晚期的几种药剂。最后，应该强调的是，再灌注损伤可能是一种慢性疾病，可能参与广泛的中枢神经系统疾病，包括与正常衰老相关的疾病。
Reperfusion injury is believed to represent an important facet of brain disease initiated by ischemia. With the continued improvement toward clinically relevant animal models of stroke and cerebrovascular injury, more direct evidence for reperfusion injury after brain ischemia will be obtained. Experimental studies should consider which outcome measures are most clinically relevant and utilize chronic histopathological and behavioral assessments to monitor outcome. Recent data indicate a complex and time-dependent sequence of microvascular and cellular responses to brain injury. The potential for pathophysiological events occurring at different reperfusion periods indicates that multiple therapeutic windows may exist for brain protection. Thus, it is conceivable that successful therapeutic strategies may ultimately involve several agents directed at the early, intermediate, and late phases of reperfusion. Finally, it should be stressed that reperfusion injury may represent a chronic condition that could potentially participate in a wide range of central nervous system disorders including those associated with normal aging.