[Circadian variations of urinary excretions of microproteins and N-acetyl-beta-D-glucosaminidase (NAG) during the ordinary activity day].
[Circadian variations of urinary excretions of microproteins and N-acetyl-beta-D-glucosaminidase (NAG) during the ordinary activity day].
复制标题
正常活动日尿中微生物蛋白和N-乙酰-β-D-氨基葡萄糖苷酶（NAG）排泄量的昼夜变化[J].
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
S. Ikawa
中科院分区：
文献类型：
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作者：
M. Suzuki;S. Ikawa
本研究旨在探讨微量蛋白尿的昼夜变化与体力活动的关系。从10名正常男性志愿者，在6个连续的4小时期间收集的尿液样本，白蛋白，α 1-，β 2-微球蛋白，NAG，电解质和激素进行了检查。心率（HR）和血压（BP）在24小时内的波动分别在30分钟和1小时的间隔进行了测量。能量消耗（EE）的计算使用之间的回归方程的HR和氧摄取量测量的另一天。将基于24小时平均值（bpm和kcal/kg/h）的HR（Δ HR）和EE（Δ EE）的变化用作普通日期间体力活动变化的指标。Δ HR与白蛋白（Δ Alb）和β 2-微球蛋白（Δ β 2 M）相对于24小时平均值（微克/h.cr 1 mg）的变化之间的相关系数分别为0.619和0.670（p <0.001）。肾小球和肾小管蛋白的分泌增加与白天活动期间HR和/或EE的增加相关。夜间休息时，α 1 M、β 2 M和NAG排泄量的变化与白蛋白的变化不同。仅在清晨（04：00-08：00）观察到肾小管蛋白排泄的暂时抑制，尽管白蛋白排泄在整个夜间都受到抑制。这些研究结果表明，体力活动可能会影响蛋白质排泄的昼夜变化，白蛋白尿可能对白天的活动更敏感，肾小管蛋白排泄的波动可能更好地由内源性机制控制。夜间或晨尿定时可作为临床糖尿病肾病筛查中微量白蛋白尿测定的样本。
The present investigation was performed to confirm the relationship between the circadian variation of microproteinuria and physical activity. Urine samples from 10 normal male volunteers, collected during six consecutive 4-h periods, were examined for albumin, alpha 1-, beta 2-microglobulin, NAG, electrolytes and hormones. The fluctuations in heart rate (HR) and blood pressure (BP) over 24-h were measured at 30-min and 1-h intervals, respectively. Energy expenditure (EE) was calculated using the equation of regression between HR and oxygen uptake measured on another day. The variations of HR (delta HR) and EE (delta EE) based on a 24-h average (bpm and kcal/kg/h) were used as indices of change in physical activity during an ordinary day. The correlation coefficients between delta HR and the variations of albumin (delta Alb) and beta 2-microglobulin (delta beta 2M) from the 24-h average (micrograms/h.cr 1 mg) were 0.619 and 0.670 (p less than 0.001), respectively. Increased excretions of both glomerular and tubular proteins were correlated with the increase in HR and/or EE during daytime activity. During rest time at night, the variations in alpha 1M, beta 2M and NAG excretion were different from the variations in albumin. A temporary inhibition of tubular protein excretion was observed only in the early morning (04:00-08:00), although albumin excretion was inhibited throughout the nighttime. These findings suggested that physical activity may influence the diurnal variations in protein excretions, that albuminuria may be more sensitive to daytime activity, and that fluctuation of tubular protein excretion may be preferably controlled by an endogenous mechanism. Timed overnight or first-morning urine may be recommendable as a sample for determination of microalbuminuria for screening of clinical diabetic nephropathy.