Impaired serum lipids and lipoproteins in fetal macrosomia related to maternal obesity
Impaired serum lipids and lipoproteins in fetal macrosomia related to maternal obesity
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DOI：
10.1159/000014190
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发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Belleville, J
中科院分区：
文献类型：
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作者：
Merzouk, H;Meghelli-Bouchenak, M;Belleville, J
这项工作的目的是确定巨大新生儿的脂蛋白代谢变化，并观察这些脂蛋白异常是否与肥胖或非肥胖母亲的脂蛋白异常相似。研究人员对肥胖和非肥胖母亲及其巨大儿或适龄 (AGA) 新生儿的脐带血进行了血清脂质、载脂蛋白 A-I、载脂蛋白 B100、脂蛋白（VLDL、LDL、HDL2 和 HDL3）和 LCAT 活性的研究。 AGA 新生儿的肥胖母亲的血清和 VLDL 甘油三酯浓度高于非肥胖母亲。与其他组相比，巨大儿肥胖母亲的血清甘油三酯、VLDL 和 apo B100 水平较高，而血清 apo A-I 和 HDL2 胆固醇浓度较低。巨大儿新生儿的血清脂质、脂蛋白、载脂蛋白 B100 和载脂蛋白 A-I 水平高于其他新生儿。非肥胖母亲的巨大新生儿的脂蛋白谱与 AGA 新生儿相似。两个母亲组和两个新生儿组的 LCAT 活性相似。总之，母亲肥胖和巨大胎儿与脂蛋白异常相关，而脂蛋白异常与高动脉粥样硬化风险一致。版权所有 (C) 2000 S. Karger AG，巴塞尔。
The aim of this work was to determine lipoprotein metabolism alterations in macrosomic newborns and to see whether these lipoprotein abnormalities are parallel or not to those found in their obese or nonobese mothers. Serum lipids, apo A-I, apo B100, lipoproteins (VLDL, LDL, HDL2, and HDL3), and LCAT activity were investigated in obese and nonobese mothers and cord blood of their macrosomic or appropriate-for-gestational-age (AGA) newborns. Serum and VLDL triglyceride concentrations were higher in obese mothers of AGA newborns than in nonobese mothers. Serum triglyceride, VLDL, and apo B100 levels were higher, while serum apo A-I and HDL2 cholesterol concentrations were lower in obese mothers of macrosomic newborns than in the other groups. In their macrosomic newborns, serum lipid, lipoprotein, apo B100, and apo A-I levels were higher as compared with those of other newborns. Macrosomic newborns of nonobese mothers had lipoprotein profiles similar to those in AGA newborns. LCAT activity was similar in both mother groups and in both newborn groups. In conclusion, maternal obesity and fetal macrosomia were associated with lipoprotein abnormalities consistent with high atherogenic risk. Copyright (C) 2000 S. Karger AG, Basel.