Continuous hyperpolarization with parahydrogen in a membrane reactor
Continuous hyperpolarization with parahydrogen in a membrane reactor
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DOI：
10.1016/j.jmr.2018.03.012
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发表时间：
2018-06-01
影响因子：
2.2
通讯作者：
Bluemich, Bernhard
中科院分区：
文献类型：
--
作者：
Lehmkuhl, Soeren;Wiese, Martin;Bluemich, Bernhard
超极化方法具有提高核磁共振灵敏度的巨大潜力。尽管“可逆交换信号放大”（SABRE）方法使用对富集氢（p-H-2）在不改变其化学结构的情况下反复在目标分子上实现高极化水平，但此类研究通常仅限于核磁共振管中的批量实验。另外，这项工作引入了一个连续流动装置，包括用于p-H-2的膜反应器，在1 T核磁共振光谱仪中供应和连续检测。两种SABRE底物吡啶和烟酰胺被超极化，发现信号增强超过1000倍。我们的策略结合了低场核磁共振光谱和膜流反应器。这样可以精确控制实验条件，如液体和气体压力，以及体积流量，以确保可重复的最大极化。(C) 2018爱思唯尔公司版权所有。
Hyperpolarization methods entail a high potential to boost the sensitivity of NMR. Even though the "Signal Amplification by Reversible Exchange" (SABRE) approach uses para-enriched hydrogen, p-H-2, to repeatedly achieve high polarization levels on target molecules without altering their chemical structure, such studies are often limited to batch experiments in NMR tubes. Alternatively, this work introduces a continuous flow setup including a membrane reactor for the p-H-2, supply and consecutive detection in a 1 T NMR spectrometer. Two SABRE substrates pyridine and nicotinamide were hyperpolarized, and more than 1000-fold signal enhancement was found. Our strategy combines low-field NMR spectrometry and a membrane flow reactor. This enables precise control of the experimental conditions such as liquid and gas pressures, and volume flow for ensuring repeatable maximum polarization. (C) 2018 Elsevier Inc. All rights reserved.