A randomised comparison of two intranasal dexmedetomidine doses for premedication in children
A randomised comparison of two intranasal dexmedetomidine doses for premedication in children
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DOI：
10.1111/j.1365-2044.2012.07309.x
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发表时间：
2012-11-01
期刊：
影响因子：
10.7
通讯作者：
Shariffuddin, I. I.
中科院分区：
文献类型：
--
作者：
Yuen, V. M.;Hui, T. W.;Shariffuddin, I. I.
We compared sedation levels in children following administration of intranasal dexmedetomidine. One hundred and sixteen children aged between 1 and 8 years were enrolled in this prospective, randomised trial. Children were assigned to receive either intranasal dexmedetomidine 1 mu g.kg-1 (Group 1) or 2 mu g.kg-1 (Group 2). Thirty-one (53%) patients from Group 1 and 38 (66%) patients from Group 2 were satisfactorily sedated at the time of anaesthetic induction. Logistic regression showed a significant interaction effect (p = 0.049), with the odds ratio between Group 2 over Group 1 estimated as 1.1 (95% CI 0.5-2.7) for the 14 year age group, and 10.5 (95% CI 1.480.2) for the 58 year age group. Both doses produced a similar level of satisfactory sedation in children aged 14 years, whereas 2 mu g.kg-1 resulted in a higher proportion of satisfactory sedation in children aged 58 years. There were no adverse haemodynamic effects. We conclude that intranasal dexmedetomidine in a premedication dose of 2 mu g.kg-1 resulted in excellent sedation in children.
