Peripheral neuropathy with IgM kappa monoclonal immunoglobulin directed against myelin‐associated glycoprotein
Peripheral neuropathy with IgM kappa monoclonal immunoglobulin directed against myelin‐associated glycoprotein
复制标题
针对髓磷脂相关糖蛋白的 IgM kappa 单克隆免疫球蛋白导致周围神经病变
DOI：
10.1212/wnl.33.11.1397
复制
发表时间：
1983
期刊：
影响因子：
9.9
通讯作者：
John Stewart
中科院分区：
文献类型：
--
作者：
C. Melmed;D. Frail;Ian Duncan;P. Braun;D. Danoff;M. Finlayson;John Stewart
3例单克隆IgM κ副蛋白血症患者有缓慢进行性节段性脱髓鞘周围神经病变。腓肠神经活检显示主要是大纤维损失，与扩大的髓鞘与活动性脱髓鞘。免疫印迹分析显示IgM与人髓磷脂的髓磷脂相关糖蛋白（MAG）反应。酶联免疫吸附试验（ELISA）的发展提供了一个简单的定量技术检测抗体的MAG。治疗与皮质类固醇，免疫抑制剂，血浆置换没有产生显着的改善。
Three patients with a monoclonal IgM kappa paraproteinemia had a slowly progressive segmental demyelinating peripheral neuropathy. Sural nerve biopsies showed predominantly large fiber loss, with widening of the intraperiod line of myelin associated with active demyelination. Immunoblot analysis showed reactivity of IgM to myelin-associated glycoprotein (MAG) of human myelin. An enzyme-linked immunosorbent assay (ELISA) was developed to provide a simple quantitative technique for detection of antibodies to MAG. Treatment with corticosteroids, immunosup-pressive agents, and plasmapheresis produced no significant improvement.