MDC1 promotes ovarian cancer metastasis by inducing epithelial-mesenchymal transition
MDC1 promotes ovarian cancer metastasis by inducing epithelial-mesenchymal transition
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DOI：
10.1007/s13277-015-3063-5
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发表时间：
2015-01
期刊：
影响因子：
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通讯作者：
Xiaoling Liu;Ruifen Dong;ZhiJun Jiang;Yuyan Wei;Yingwei Li;Linxuan Wei;Hengzi Sun;Yinuo Li;Ning Yang;Qifeng Yang;Zhaojian Liu;B. Kong
中科院分区：
文献类型：
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作者：
Xiaoling Liu;Ruifen Dong;ZhiJun Jiang;Yuyan Wei;Yingwei Li;Linxuan Wei;Hengzi Sun;Yinuo Li;Ning Yang;Qifeng Yang;Zhaojian Liu;B. Kong
Ovarian cancer is a highly invasive cancer with poor prognosis. Previous studies have revealed lots of connections between the invasiveness and epithelial-mesenchymal transition (EMT), which is common during the progression of ovarian cancer.MDC1, a mediator of DNA damage checkpoint, has recently been implicated as a potential oncogene. Here, in this article, we studied the role ofMDC1in ovarian cancer metastasis. First, in tissue samples, we found that high expression level of MDC1 was correlated with poor prognosis. Furthermore,MDC1overexpression in ovarian cancer cells significantly increased migration and invasion. In contrast, silencingMDC1reversed these processes. Consistently, nude mice xenograft confirmed that silencingMDC1suppressed tumor metastasis in vivo. We further demonstrated thatMDC1induced EMT through modulation EMT markers such as E-cadherin, N-cadherin, and vimentin. Taken together, our findings suggest thatMDC1promotes ovarian cancer metastasis through the induction of EMT.
