Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes.
Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes.
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DOI：
10.1016/j.cmet.2015.06.010
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发表时间：
2015-09-01
期刊：
影响因子：
29
通讯作者：
Hotamisligil GS
中科院分区：
文献类型：
--
作者：
Arruda AP;Hotamisligil GS
许多慢性代谢疾病，包括肥胖症、糖尿病、心血管疾病、哮喘和癌症聚集在一起，对人类健康构成最大的威胁。随着该领域研究的进展，已经清楚的是，未解决的代谢炎症、细胞器功能障碍以及其他细胞和代谢应激是这些慢性代谢疾病发展的基础。然而，这些系统和病理机制之间的关系知之甚少。在这里，我们将讨论细胞内钙稳态的作用，作为一个关键的机制，整合了无数的细胞和亚细胞功能障碍的网络中发现的代谢组织，如肝脏和脂肪组织的背景下，代谢疾病，特别是在肥胖症和糖尿病。
A number of chronic metabolic pathologies, including obesity, diabetes, cardiovascular disease, asthma, and cancer cluster together to present the greatest threat to human health. As research in this field has advanced, it has become clear that unresolved metabolic inflammation, organelle dysfunction, and other cellular and metabolic stresses underlie the development of these chronic metabolic diseases. However, the relationship between these systems and pathological mechanisms is poorly understood. Here, we will discuss the role of cellular Ca2+ homeostasis as a critical mechanism integrating the myriad of cellular and subcellular dysfunctional networks found in metabolic tissues such as liver and adipose tissue in the context of metabolic disease particularly in obesity and diabetes.