International Consensus (ICON): allergic reactions to vaccines
International Consensus (ICON): allergic reactions to vaccines
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DOI：
10.1186/s40413-016-0120-5
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发表时间：
2016-09-16
影响因子：
5.1
通讯作者：
Rosenwasser, Lanny J.
中科院分区：
文献类型：
--
作者：
Dreskin, Stephen C.;Halsey, Neal A.;Rosenwasser, Lanny J.
背景：常规免疫是最有效的公共卫生干预措施之一，有效降低了多种传染病造成的死亡和发病率。然而，疫苗过敏反应很少发生，并且可能危及生命。鉴于全球范围内注射的疫苗数量众多，需要就疫苗过敏反应的评估和管理达成国际共识。 方法：在查阅文献后，在世界过敏组织（WAO）、欧洲过敏和临床免疫学学会（EAACI）、美国过敏、哮喘和免疫学学会（AAAAI）以及美国过敏、哮喘和免疫学学会（ACAAI）代表的积极参与下，最终委员会成立的目的是让成员代表广泛的国家，以前从事疫苗安全工作，包括变态反应学家/免疫学家以及疫苗学家。结果：就各种主题达成共识，包括：立即过敏反应的定义，包括过敏反应，区分关联与因果关系的方法，对既往疫苗有过敏反应史的患者的处理方法，以及对疫苗成分有过敏反应史的患者的处理方法。结论：文件提供了全面且国际公认的指南以及在线文件的访问权限，以帮助世界各地的从业者识别免疫后的过敏反应。它还为对疫苗过敏反应或对疫苗成分有过敏史的患者进行评估和进一步管理提供了框架。
Background: Routine immunization, one of the most effective public health interventions, has effectively reduced death and morbidity due to a variety of infectious diseases. However, allergic reactions to vaccines occur very rarely and can be life threatening. Given the large numbers of vaccines administered worldwide, there is a need for an international consensus regarding the evaluation and management of allergic reactions to vaccines.Methods: Following a review of the literature, and with the active participation of representatives from the World Allergy Organization (WAO), the European Academy of Allergy and Clinical Immunology (EAACI), the American Academy of Allergy, Asthma, and Immunology (AAAAI), and the American College of Allergy, Asthma, and Immunology (ACAAI), the final committee was formed with the purpose of having members who represented a wide-range of countries, had previously worked on vaccine safety, and included both allergist/immunologists as well as vaccinologists.Results: Consensus was reached on a variety of topics, including: definition of immediate allergic reactions, including anaphylaxis, approaches to distinguish association from causality, approaches to patients with a history of an allergic reaction to a previous vaccine, and approaches to patients with a history of an allergic reaction to components of vaccines.Conclusions: This document provides comprehensive and internationally accepted guidelines and access to on-line documents to help practitioners around the world identify allergic reactions following immunization. It also provides a framework for the evaluation and further management of patients who present either following an allergic reaction to a vaccine or with a history of allergy to a component of vaccines.