Signals and Switches in Mammalian Neural Crest Cell Differentiation
Signals and Switches in Mammalian Neural Crest Cell Differentiation
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DOI：
10.1101/cshperspect.a008326
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发表时间：
2013-02-01
影响因子：
7.2
通讯作者：
Trainor, Paul A.
中科院分区：
文献类型：
--
作者：
Bhatt, Shachi;Diaz, Raul;Trainor, Paul A.
神经脊细胞(NCC)包括一个多能的、可迁移的细胞群，在脊椎动物发育过程中产生一系列不同的细胞和组织类型。这些细胞包括软骨和骨、肌腱和结缔组织，以及神经元、神经胶质细胞、黑素细胞、内分泌和脂肪细胞；这种非凡的谱系潜力将持续到成年。与有限的自我更新能力相结合，神经脊细胞具有干细胞和祖细胞的特征，被认为是脊椎动物进化的同义词。神经脊提供了一个系统，用于探索控制发育过程的机制，如形态发生诱导、细胞迁移和命运决定。今天，对神经脊细胞的大部分关注都围绕着它们的干细胞样特征和用于再生医学的潜力。彻底了解支配哺乳动物神经脊模式的信号和开关对于这些细胞的潜在治疗应用和更好地了解神经脊细胞在脊椎动物进化、发育和疾病中所起的作用至关重要。
Neural crest cells (NCCs) comprise a multipotent, migratory cell population that generates a diverse array of cell and tissue types during vertebrate development. These include cartilage and bone, tendons, and connective tissue, as well as neurons, glia, melanocytes, and endocrine and adipose cells; this remarkable lineage potential persists into adult life. Taken together with a limited capacity for self-renewal, neural crest cells bear the hallmarks of stem and progenitor cells and are considered to be synonymous with vertebrate evolution. The neural crest has provided a system for exploring the mechanisms that govern developmental processes such as morphogenetic induction, cell migration, and fate determination. Today, much of the focus on neural crest cells revolves around their stem cell-like characteristics and potential for use in regenerative medicine. A thorough understanding of the signals and switches that govern mammalian neural crest patterning is central to potential therapeutic application of these cells and better appreciation of the role that neural crest cells play in vertebrate evolution, development, and disease.