Phantom percepts: Tinnitus and pain as persisting aversive memory networks
Phantom percepts: Tinnitus and pain as persisting aversive memory networks
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DOI：
10.1073/pnas.1018466108
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发表时间：
2011-05-17
影响因子：
11.1
通讯作者：
Langguth, Berthold
中科院分区：
文献类型：
--
作者：
De Ridder, Dirk;Elgoyhen, Ana Belen;Langguth, Berthold
幻影知觉是指在没有外部刺激的情况下对被感知者的有意识的感知。在神经科学基础理论和幻痛、幻声的临床研究基础上，提出了幻痛、幻声产生的工作模型。感觉传入阻滞导致感觉皮层中的高频、伽马带、同步神经元活动。只有当这种活动与更大的共同激活的“（自我）意识”和“显着性”大脑网络相联系时，它才能成为一种有意识的接受。通过学习机制的参与，幻肢感受器变得与痛苦相关，这反过来又反映在由前扣带皮层、前扣带皮层和杏仁核组成的同时共激活的非特异性痛苦网络上。记忆机制在持续意识到幻肢的存在以及强化相关的痛苦方面发挥着作用。因此，不同的动态重叠脑网络应被视为治疗这种疾病的目标。
Phantom perception refers to the conscious awareness of a percept in the absence of an external stimulus. On the basis of basic neuroscience on perception and clinical research in phantom pain and phantom sound, we propose a working model for their origin. Sensory deafferentation results in high-frequency, gamma band, synchronized neuronal activity in the sensory cortex. This activity becomes a conscious percept only if it is connected to larger coactivated "(self-)awareness" and "salience" brain networks. Through the involvement of learning mechanisms, the phantom percept becomes associated to distress, which in turn is reflected by a simultaneously coactivated nonspecific distress network consisting of the anterior cingulate cortex, anterior insula, and amygdala. Memory mechanisms play a role in the persistence of the awareness of the phantom percept, as well as in the reinforcement of the associated distress. Thus, different dynamic overlapping brain networks should be considered as targets for the treatment of this disorder.