Allelic imbalance in the miR-31 host gene locus in lung cancer--its potential role in carcinogenesis.
Allelic imbalance in the miR-31 host gene locus in lung cancer--its potential role in carcinogenesis.
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DOI：
10.1371/journal.pone.0100581
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Ohashi K
中科院分区：
文献类型：
--
作者：
Okudela K;Tateishi Y;Umeda S;Mitsui H;Suzuki T;Saito Y;Woo T;Tajiri M;Masuda M;Miyagi Y;Ohashi K
最近发现的小分子非蛋白编码RNA，microRNA(MiR)，调节信使RNA水平，可能在多种疾病的发病机制中发挥重要作用。本研究的重点是miR-31，并探讨其在肺癌发生中的潜在作用。MiR-31在肺癌细胞中的表达通过宿主基因位点的扩增或缺失而发生改变。MiR-31在大细胞癌中的强表达与基因扩增有关。同时，miR-31的表达缺失在侵袭性腺癌中更为常见。因此，miR-31可能在不同组织类型肺癌的发生发展中起多向作用。据我们所知，这是第一个显示miR-31表达改变的潜在原因机制的研究，并表明其在不同组织类型的肺癌中可能具有不同的意义。
Small non-protein coding RNA, microRNA (miR), which regulate messenger RNA levels, have recently been identified, and may play important roles in the pathogenesis of various diseases. The present study focused on miR-31 and investigated its potential involvement in lung carcinogenesis. The expression of miR-31 was altered in lung cancer cells through either the amplification or loss of the host gene locus. The strong expression of miR-31 in large cell carcinomas was attributed to the gene amplification. Meanwhile, the loss of miR-31 expression was more frequently observed in aggressive adenocarcinomas. Thus, miR-31 may play a pleiotropic role in the development of lung cancers among different histological types. To the best of our knowledge, this is the first study to show the potential causative mechanism of the altered expression of miR-31 and suggest its potentially diverse significance in the different histological types of lung cancers.
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DOI：
10.1158/1541-7786.mcr-11-0311
发表时间：
2011-11
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Augoff K;Das M;Bialkowska K;McCue B;Plow EF;Sossey-Alaoui K
通讯作者：
Sossey-Alaoui K
DOI：
10.1158/1078-0432.ccr-11-2857
发表时间：
2012-07-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Jang JS;Jeon HS;Sun Z;Aubry MC;Tang H;Park CH;Rakhshan F;Schultz DA;Kolbert CP;Lupu R;Park JY;Harris CC;Yang P;Jen J
通讯作者：
Jen J
影响因子：
37.3
作者：
Augoff K;McCue B;Plow EF;Sossey-Alaoui K
通讯作者：
Sossey-Alaoui K
影响因子：
6
作者：
Okudela, Koji;Yazawa, Takuya;Kitamura, Hitoshi
通讯作者：
Kitamura, Hitoshi
影响因子：
4.8
作者：
Cottonham, Charisa L.;Kaneko, Satoshi;Xu, Lan
通讯作者：
Xu, Lan