Malaria and pregnancy: Placental cytokine expression and its relationship to intrauterine growth retardation
Malaria and pregnancy: Placental cytokine expression and its relationship to intrauterine growth retardation
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DOI：
10.1086/315135
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发表时间：
1999-12-01
影响因子：
6.4
通讯作者：
Meshnick, SR
中科院分区：
文献类型：
--
作者：
Moormann, AM;Sullivan, AD;Meshnick, SR
怀孕期间感染疟疾可导致出生体重不足的婴儿。在这项研究中，细胞因子mRNA的测量胎盘从23疟疾感染和21未感染的早孕妇女谁交付Mangochi，马拉维，一个地区的恶性疟疾的传播率很高。与未感染胎盘相比，疟疾感染胎盘中白细胞介素（IL）-1 β、IL-8和肿瘤坏死因子（TNF）-α的表达显著增加，IL-6和转化生长因子-β 1的表达降低。TNF-α和IL-8由母体来源的装载有疟原虫色素的胎盘巨噬细胞产生。TNF-α表达增加与胎盘色素浓度增加相关。胎盘中TNF-α或IL-8表达的增加与宫内发育迟缓有关，但与早产无关。结果表明，疟疾感染在胎盘中诱导了潜在有害的促炎反应。
Malaria infections during pregnancy can lead to the delivery of low-birth-weight infants. In this study, cytokine mRNA was measured in placentas from 23 malaria-infected and 21 uninfected primigravid women who had delivered in Mangochi, Malawi, a region with a high rate of transmission of falciparum malaria. Significantly increased expression of interleukin (IL)-1 beta, IL-8, and tumor necrosis factor (TNF)-alpha and decreased expression of IL-6 and transforming growth factor-beta 1 were found in malaria-infected compared with uninfected placentas. TNF-alpha and IL-8 were produced by maternally derived hemozoin-laden placental macrophages. Increased TNF-alpha expression was associated with increased placental hemozoin concentrations. Increased TNF-alpha or IL-8 expression in the placenta was associated with intrauterine growth retardation hut not with preterm delivery. The results suggest that malaria infections induce a potentially harmful proinflammatory response in the placenta.