Activated Akt as an indicator of prognosis in gastric cancer
Activated Akt as an indicator of prognosis in gastric cancer
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DOI：
10.1007/s00428-008-0676-8
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发表时间：
2008-11-01
期刊：
影响因子：
3.5
通讯作者：
Tosi, Piero
中科院分区：
文献类型：
--
作者：
Cinti, Caterina;Vindigni, Carla;Tosi, Piero
本文分析了50例进展期胃癌组织中磷酸化(活化)Akt蛋白的免疫组织化学表达，结果与年龄、性别、胃部位、组织类型、分期、生存期、有丝分裂指数、细胞凋亡指数、某些细胞周期调控因子(细胞周期蛋白D1、细胞周期蛋白E、p34/cdc2、p27/kip1)及细胞增殖有关。PAKT的表达(胞浆和胞核)与肿瘤的浸润深度、受累淋巴结数目和p34/cdc2的表达呈正相关，与细胞周期蛋白D1和细胞周期蛋白E的表达呈正相关，与细胞凋亡指数、胞浆和胞核的PAKT与患者的生存呈显著负相关。PAKT与性别、年龄、肿瘤部位、组织类型、有丝分裂指数和细胞增殖无关。这些发现表明，PAKT可能被认为是胃癌患者肿瘤进展和患者生存的一个指标。
The immunohistochemical expression of phosphorylated (activated) Akt (pAkt) in 50 advanced gastric carcinomas has been analyzed and the results correlated with age, sex, location in the stomach, histotype, stage, survival, mitotic and apoptotic index, some cell cycle regulators (cyclin D1, cyclin E, p34/cdc2, p27/kip1), and cell proliferation. There was a statistically significant direct correlation between pAkt expression (both cytoplasmatic and nuclear) and depth of infiltration of the tumor, number of infiltrated lymph nodes and p34/cdc2 expression, and between prevalently nuclear pAkt and cyclin D1 and cyclin E. Conversely, there was a significant inverse correlation between nuclear pAkt and apoptotic index and between cytoplasmatic and nuclear pAkt and patient survival. No correlation was found between pAkt and sex, age, tumor location, histotype, mitotic index, and cell proliferation. These findings suggest that pAkt may be considered an indicator of tumor progression and patient survival in gastric cancer.