Comparison of prevalence of chronic atrophic gastritis in Japan, China, Tanzania, and the Dominican Republic
Comparison of prevalence of chronic atrophic gastritis in Japan, China, Tanzania, and the Dominican Republic
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DOI：
10.1016/j.annepidem.2004.11.002
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发表时间：
2005-09-01
影响因子：
5.6
通讯作者：
Misumi, J
中科院分区：
文献类型：
--
作者：
Aoki, K;Kihaile, PE;Misumi, J
目得：比较日本、中国、坦桑尼亚和多米尼加共和国慢性萎缩性胃炎（CAG）的患病率，并评估幽门螺杆菌感染和血清胃泌素水平作为CAG标志物的有用性。受试者是来自日本（n = 859）、中国（n = 1741）、坦桑尼亚（n = 573）和多米尼加共和国（n = 1215）当地社区的志愿者。每名受试者均接受健康检查，并采集血样用于测量血清胃蛋白酶原I和II、胃蛋白酶原I/II比值、血清胃泌素和H。pylori抗体水平，并对上消化道疾病进行问卷调查。pylori感染（23.5-96.1%）、CAG（5.6-60.4%）和血清胃泌素（62.0-136.5 pg/ml）因年龄、性别和国家而异。每个国家男子的血清胃泌素水平因年龄而异。在坦桑尼亚男性中，胃泌素水平中位数（101.0 pg/ml）在40 - 49岁年龄组中最高（p < 0.01），而坦桑尼亚女性中不同年龄组之间无显著差异。在多米尼加共和国，年龄≥ 70岁的男女受试者的血清胃泌素水平高于其他年龄组（男性，92.5 pg/ml，女性，136.5 pg/ml）。H.在日本（仅女性）和多米尼加共和国，幽门螺杆菌感染随着年龄的增长而增加（p < 0.01），但在中国和坦桑尼亚，所有年龄组的男女感染率都很高。在日本、中国（仅女性）和多米尼加共和国，CAG的患病率随着年龄的增长而增加（p < 0.01），但在坦桑尼亚没有。H. pylori感染者是H.幽门阴性受试者。血清胃泌素水平每升高1 pg/ml，CAG的优势比增加0.6%。pylori感染、血清胃泌素和年龄增长是CAG的良好标志物，并且CAG的患病率在日本最高。
PURPOSE: To compare the prevalence of chronic atrophic gastritis (CAG) in Japan, China, Tanzania, and the Dominican Republic and to assess the usefulness of Helicobacter pylori infection and serum gastrin level as markers of CAG.METHODS: The subjects were volunteers from local communities in Japan (n = 859), China (n = 1741), Tanzania (n = 573), and the Dominican Republic (n = 1215). Each individual underwent a health checkup and blood sampling for measurement of serum pepsinogen I and II, pepsinogen I/II ratio, serum gastrin, and H. pylori antibodies, and responded to a questionnaire on upper digestive tract diseases.RESULTS: The prevalences of H. pylori infection (23.5-96.1%), CAG (5.6-60.4%), and serum gastrin (62.0-136.5 pg/ml) varied by age, sex, and country. Serum gastrin level for men differed in each country according to age. In Tanzanian men, the median gastrin level (101.0 pg/ml) was the highest in the 40 to 49 years age group (p < 0.01) while there was no significant difference among different age groups in Tanzanian women. Serum gastrin level in subjects >= 70 years was higher than in other age groups in both sexes in the Dominican Republic (males, 92.5, females, 136.5 pg/ml). The prevalence of H. pylori infection increased (p < 0.01) with advancing age in Japan (only for women) and the Dominican Republic but was high in all age groups of both sexes in China and Tanzania. The prevalence of CAG increased (p < 0.01) with age in both sexes in Japan, China (women only), and the Dominican Republic, but not in Tanzania. The odds ratio of CAG in H. pylori infected subjects was 5.3 times that in H. pylori-negative subjects. The odds ratio of CAG increased by 0.6%/l pg/ml increase in serum gastrin.CONCLUSIONS: Our results indicated that H. pylori infection, serum gastrin, and advancing age are good markers of CAG and that the prevalence of CAG is the highest in Japan.