Quality assessment of tandem mass spectra based on cumulative intensity normalization
Quality assessment of tandem mass spectra based on cumulative intensity normalization
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DOI：
10.1021/pr0603248
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发表时间：
2006-12-01
影响因子：
4.4
通讯作者：
Paek, Eunok
中科院分区：
文献类型：
--
作者：
Na, Seungjin;Paek, Eunok
很大一部分MS/MS光谱分析不会导致显著匹配，因为它们的光谱质量太差，无法产生有意义的鉴别。如果能够预先过滤掉可能导致错误鉴定的光谱，则可以大大提高肽鉴定的准确性。我们在这里介绍一种创新的方法来评估光谱质量，利用一个新的光谱特征称为Xrea，基于累积强度归一化。
A large proportion of MS/MS spectral analyses do not result in significant matches because their spectral quality is too poor to produce meaningful identification. Throughput of peptide identification can be greatly improved, if one can filter out, in advance, spectra that would lead to wrong identification. We introduce here an innovative approach to assess spectral quality utilizing a new spectral feature called Xrea, based on cumulative intensity normalization.