Postepidemic Analysis of Rift Valley Fever Virus Transmission in Northeastern Kenya: A Village Cohort Study
Postepidemic Analysis of Rift Valley Fever Virus Transmission in Northeastern Kenya: A Village Cohort Study
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DOI：
10.1371/journal.pntd.0001265
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发表时间：
2011-08-01
影响因子：
3.8
通讯作者：
King, Charles H.
中科院分区：
文献类型：
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作者：
LaBeaud, A. Desiree;Muiruri, Samuel;King, Charles H.
背景：裂谷热病毒（RVFV）在流行地区对人类和动物健康都是一个重大威胁。本研究的目标是测量2006-2007年肯尼亚裂谷热（RVF）流行后高风险地区的人类抗RVFV血清阳性率，以确定间隔血清转换的风险因素，并监测先前暴露于RVFV的个体以记录其抗RVFV抗体的持续性。方法/结果：我们在肯尼亚东北省Ijara区进行了一项村庄队列研究。对2006-2007年裂谷热爆发前接受RVFV暴露检测的102名个体进行了重新研究，以确定自2006年以来的间隔抗RVFV血清转换和体液免疫的持续性。从随机选择的家庭中招募了92名额外的受试者，以帮助确定当前血清阳性的风险因素。总体而言，44/194或23%（CI 95%：17%-29%）的当地居民RVFV血清阳性。自2006年初以来，在随访队列中重新研究的85名高危个体中有1人发生血清转化。27/92（29%，CI 95%：20%-39%）的新检测个体为血清阳性。2006年效价呈阳性的所有13名个体（通过空斑减少中和试验（PRNT 80））在2009年仍然呈阳性。多变量logistic模型校正后，年龄、村庄和饮用生牛奶与RVFV血清阳性显著相关。视力障碍（定义为
Background: In endemic areas, Rift Valley fever virus (RVFV) is a significant threat to both human and animal health. Goals of this study were to measure human anti-RVFV seroprevalence in a high-risk area following the 2006-2007 Kenyan Rift Valley Fever (RVF) epidemic, to identify risk factors for interval seroconversion, and to monitor individuals previously exposed to RVFV in order to document the persistence of their anti-RVFV antibodies.Methodology/Findings: We conducted a village cohort study in Ijara District, Northeastern Province, Kenya. One hundred two individuals tested for RVFV exposure before the 2006-2007 RVF outbreak were restudied to determine interval anti-RVFV seroconversion and persistence of humoral immunity since 2006. Ninety-two additional subjects were enrolled from randomly selected households to help identify risk factors for current seropositivity. Overall, 44/194 or 23% (CI95%:17%-29%) of local residents were RVFV seropositive. 1/85 at-risk individuals restudied in the follow-up cohort had seroconverted since early 2006. 27/92 (29%, CI95%:20%-39%) of newly tested individuals were seropositive. All 13 individuals with positive titers (by plaque reduction neutralization testing (PRNT80)) in 2006 remained positive in 2009. After adjustment in multivariable logistic models, age, village, and drinking raw milk were significantly associated with RVFV seropositivity. Visual impairment (defined as