Maintaining proteostasis under mechanical stress.
Maintaining proteostasis under mechanical stress.
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DOI：
10.15252/embr.202152507
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发表时间：
2021-08-04
期刊：
影响因子：
7.7
通讯作者：
Warscheid B
中科院分区：
文献类型：
--
作者：
Höhfeld J;Benzing T;Bloch W;Fürst DO;Gehlert S;Hesse M;Hoffmann B;Hoppe T;Huesgen PF;Köhn M;Kolanus W;Merkel R;Niessen CM;Pokrzywa W;Rinschen MM;Wachten D;Warscheid B
细胞存活、组织完整性和生物体健康取决于即使在威胁蛋白质完整性的条件下维持功能性蛋白质网络的能力。针对这种应激条件的保护涉及折叠和降解机制的适应，这有助于通过促进受损蛋白质的重折叠或处置来保护蛋白质网络。在多细胞生物体中，细胞永久地暴露于由机械力引起的应力。然而，长期以来，机械应力并没有被认为是干扰蛋白质结构和威胁蛋白质组完整性的主要应激源。蛋白质折叠和降解系统的鉴定和表征，处理力-未折叠的蛋白质，标志着这方面的转折点。很明显，机械应力保护在细胞分化、粘附和迁移期间起作用，并且对于维持组织如骨骼肌、心脏和肾脏以及免疫系统是必不可少的。在这里，我们提供了一个概述，我们了解机械应力保护的最新进展。细胞经常受到机械应力的作用。这篇综述讨论了分子伴侣和蛋白质降解系统如何处理强制展开的蛋白质，以保持蛋白质在机械应激细胞和组织中的稳态。
Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or disposal of damaged proteins. In multicellular organisms, cells are permanently exposed to stress resulting from mechanical forces. Yet, for long time mechanical stress was not recognized as a primary stressor that perturbs protein structure and threatens proteome integrity. The identification and characterization of protein folding and degradation systems, which handle force‐unfolded proteins, marks a turning point in this regard. It has become apparent that mechanical stress protection operates during cell differentiation, adhesion and migration and is essential for maintaining tissues such as skeletal muscle, heart and kidney as well as the immune system. Here, we provide an overview of recent advances in our understanding of mechanical stress protection. Cells are constantly subjected to mechanical stress. This review discusses how chaperone and protein degradation systems handle force‐unfolded proteins to preserve protein homeostasis in mechanically stressed cells and tissues.
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DOI：
10.1126/science.1254211
发表时间：
2014-10-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Buckley CD;Tan J;Anderson KL;Hanein D;Volkmann N;Weis WI;Nelson WJ;Dunn AR
通讯作者：
Dunn AR
影响因子：
21.3
作者：
Austen K;Ringer P;Mehlich A;Chrostek-Grashoff A;Kluger C;Klingner C;Sabass B;Zent R;Rief M;Grashoff C
通讯作者：
Grashoff C
影响因子：
14.5
作者：
Adriaenssens, Elias;Geuens, Thomas;Timmerman, Vincent
通讯作者：
Timmerman, Vincent
影响因子：
6
作者：
Bazzaro, Martina;Santillan, Antonio;Roden, Richard B. S.
通讯作者：
Roden, Richard B. S.
影响因子：
56.9
作者：
Barral, JM;Hutagalung, AH;Epstein, HF
通讯作者：
Epstein, HF