The cortical connectivity of the periaqueductal gray and tha conditioned response to the threat of breathlessness
The cortical connectivity of the periaqueductal gray and tha conditioned response to the threat of breathlessness
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DOI：
10.7554/elife.21749
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发表时间：
2017-02-17
期刊：
影响因子：
7.7
通讯作者：
Pattinson, Kyle T. S.
中科院分区：
文献类型：
--
作者：
Faull, Olivia K.;Pattinson, Kyle T. S.
先前我们观察到在呼吸困难及其条件性预期期间导水管周围灰质（PAG）的各个柱中的差异激活（Faull等人，2016年b）。在这里，我们通过确定PAG的各个列如何与更高的皮层中心相互作用，在休息和呼吸困难威胁的情况下，扩展了这项工作。在腹外侧PAG（vlPAG）和外侧PAG（lPAG）中观察到激活，其中活动与呼吸困难强度评级成比例，揭示了呼吸困难期间感觉和认知之间的潜在界面。在休息时，lPAG与皮质感觉运动区功能相关，有利于促进战斗/逃跑反应，并表现出增加的同步性与杏仁核在呼吸困难。vlPAG在休息时表现出额叶-边缘系统的相关性，而在呼吸困难预期期间，lPAG和运动结构的功能同步性降低，有助于冻结行为。这些结果使我们进一步了解PAG如何复杂地参与人类对威胁的反应。
Previously we observed differential activation in individual columns of the periaqueductal grey (PAG) during breathlessness and its conditioned anticipation (Faull et al., 2016b). Here, we have extended this work by determining how the individual columns of the PAG interact with higher cortical centres, both at rest and in the context of breathlessness threat. Activation was observed in ventrolateral PAG (vlPAG) and lateral PAG (lPAG), where activity scaled with breathlessness intensity ratings, revealing a potential interface between sensation and cognition during breathlessness. At rest the lPAG was functionally correlated with cortical sensorimotor areas, conducive to facilitating fight/flight responses, and demonstrated increased synchronicity with the amygdala during breathlessness. The vlPAG showed fronto-limbic correlations at rest, whereas during breathlessness anticipation, reduced functional synchronicity was seen to both lPAG and motor structures, conducive to freezing behaviours. These results move us towards understanding how the PAG might be intricately involved in human responses to threat.